Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150531844> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W3150531844 abstract "Objective A Rhesus monkey model was employed to study the radioprotective effects of a Toll-like receptor 5 agonist, CBLB502, against 7.0Gy whole-body irradiation of 60 Co gamma-rays. Methods Thirty animals were assigned to a placebo treatment group, a WR-2721 positive control group, and three CBLB502 treatment groups(n=6 animals/group). Each animal was irradiated with 7.0Gy 60 Co γ and given CBLB502 at 2.5, 10 and 40μg/kg, respectively in treatment groups, or WR-2721 at 30mg/kg, or physiological saline 0.3ml/kg for the placebo treatment group. The treatment was given once by intramuscular injection 30 min before irradiation. All irradiated animals received symptomatic treatment based on same guidelines. General observation, peripheral blood tests, hemopoietic progenitor cell colony-counting, and histopathological examination were performed. Results We found that 10 or 40μg/kg CBLB502 treatment resulted in 100% survival, while the survival rate was 33% in placebo treatment group. Hematopoietic recovery in the WR-2721 treatment group was marginally superior to the irradiation control group. Nadirs of peripheral white cell and platelet counts of animals treated with 40μg/kg of CBLB502 were significantly higher than those of the placebo treatment group(P0.05). CBLB502 at 40μg/kg also gave a shortened duration of low platelet count, earlier recovery time, reduced the amount of blood transfusion and damage to the bone marrow and intestine. Conclusion All Rhesus monkeys irradiated with 7.0Gy 60 Co γ-rays would suffer from severe acute radiation sickness of hematopoietic system. CBLB502 at 40μg/kg is radioprotective in thismodel and a single intramuscular injection of CBLB502 in a dose of 40μg/kg 30 min before irradiation gives better radioprotective effects than WR-2721." @default.
- W3150531844 created "2021-04-13" @default.
- W3150531844 creator A5012435102 @default.
- W3150531844 date "2015-01-01" @default.
- W3150531844 modified "2023-09-23" @default.
- W3150531844 title "Radioprotective effects of CBLB502 on γ-radiated Rhesus monkey" @default.
- W3150531844 hasPublicationYear "2015" @default.
- W3150531844 type Work @default.
- W3150531844 sameAs 3150531844 @default.
- W3150531844 citedByCount "0" @default.
- W3150531844 crossrefType "journal-article" @default.
- W3150531844 hasAuthorship W3150531844A5012435102 @default.
- W3150531844 hasConcept C109159458 @default.
- W3150531844 hasConcept C126322002 @default.
- W3150531844 hasConcept C142724271 @default.
- W3150531844 hasConcept C204787440 @default.
- W3150531844 hasConcept C27081682 @default.
- W3150531844 hasConcept C2776694085 @default.
- W3150531844 hasConcept C2776755627 @default.
- W3150531844 hasConcept C2777397205 @default.
- W3150531844 hasConcept C2778488018 @default.
- W3150531844 hasConcept C2778880498 @default.
- W3150531844 hasConcept C2780007613 @default.
- W3150531844 hasConcept C28328180 @default.
- W3150531844 hasConcept C2989005 @default.
- W3150531844 hasConcept C54355233 @default.
- W3150531844 hasConcept C71924100 @default.
- W3150531844 hasConcept C86803240 @default.
- W3150531844 hasConcept C89560881 @default.
- W3150531844 hasConcept C90924648 @default.
- W3150531844 hasConceptScore W3150531844C109159458 @default.
- W3150531844 hasConceptScore W3150531844C126322002 @default.
- W3150531844 hasConceptScore W3150531844C142724271 @default.
- W3150531844 hasConceptScore W3150531844C204787440 @default.
- W3150531844 hasConceptScore W3150531844C27081682 @default.
- W3150531844 hasConceptScore W3150531844C2776694085 @default.
- W3150531844 hasConceptScore W3150531844C2776755627 @default.
- W3150531844 hasConceptScore W3150531844C2777397205 @default.
- W3150531844 hasConceptScore W3150531844C2778488018 @default.
- W3150531844 hasConceptScore W3150531844C2778880498 @default.
- W3150531844 hasConceptScore W3150531844C2780007613 @default.
- W3150531844 hasConceptScore W3150531844C28328180 @default.
- W3150531844 hasConceptScore W3150531844C2989005 @default.
- W3150531844 hasConceptScore W3150531844C54355233 @default.
- W3150531844 hasConceptScore W3150531844C71924100 @default.
- W3150531844 hasConceptScore W3150531844C86803240 @default.
- W3150531844 hasConceptScore W3150531844C89560881 @default.
- W3150531844 hasConceptScore W3150531844C90924648 @default.
- W3150531844 hasLocation W31505318441 @default.
- W3150531844 hasOpenAccess W3150531844 @default.
- W3150531844 hasPrimaryLocation W31505318441 @default.
- W3150531844 hasRelatedWork W2080339020 @default.
- W3150531844 hasRelatedWork W2083121027 @default.
- W3150531844 hasRelatedWork W2112002831 @default.
- W3150531844 hasRelatedWork W2279779568 @default.
- W3150531844 hasRelatedWork W2321681738 @default.
- W3150531844 hasRelatedWork W2347467813 @default.
- W3150531844 hasRelatedWork W2352030056 @default.
- W3150531844 hasRelatedWork W2352117863 @default.
- W3150531844 hasRelatedWork W2357240411 @default.
- W3150531844 hasRelatedWork W2374070488 @default.
- W3150531844 hasRelatedWork W2380549520 @default.
- W3150531844 hasRelatedWork W2399990341 @default.
- W3150531844 hasRelatedWork W2410088421 @default.
- W3150531844 hasRelatedWork W2418914690 @default.
- W3150531844 hasRelatedWork W2464036986 @default.
- W3150531844 hasRelatedWork W2557739343 @default.
- W3150531844 hasRelatedWork W2789746034 @default.
- W3150531844 hasRelatedWork W3028703496 @default.
- W3150531844 hasRelatedWork W3031591794 @default.
- W3150531844 hasRelatedWork W37303631 @default.
- W3150531844 isParatext "false" @default.
- W3150531844 isRetracted "false" @default.
- W3150531844 magId "3150531844" @default.
- W3150531844 workType "article" @default.