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- W3150552574 abstract "AIM:To systematically study the expression of carbonic anhydrase (CA) isozymes Ⅸ and Ⅻ in gastric tumors. METHODS:We analyzed a representative series of specimens from non-neoplastic gastric mucosa and from various dysplastic and neoplastic gastric lesions for the expression of CA Ⅸ and Ⅻ.Immunohistochemical staining was performed using isozyme-specific antibodies and biotin- streptavidin complex method. RESULTS:CA IX was highly expressed in the normal gastric mucosa and remained positive in many gastric tumors.In adenomas,CA Ⅸ expression significantly decreased towards the high grade dysplasia.However,the expression resumed back to the normal level in well differentiated adenocarcinomas, while it again declined in carcinomas with less differentiation. In comparison,CA Ⅻ showed no or weak immunoreaction in the normal gastric mucosa and was slightly increased in tumors. CONCLUSION:These results demonstrate that CA Ⅸ expression is sustained in several types of gastric tumors. The variations observed in the CA Ⅸ levels support the concept that gastric adenomas and carcinomas are distinct entities and do not represent progressive steps of a single pathway." @default.
- W3150552574 created "2021-04-13" @default.
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- W3150552574 date "2003-01-01" @default.
- W3150552574 modified "2023-09-23" @default.
- W3150552574 title "Carbonic anhydrase isozymes XI and XII in gastric tumors" @default.
- W3150552574 hasPublicationYear "2003" @default.
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