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- W3150584817 abstract "ObjectiveTo investigate the expression and significance of CD133 and β-catenin in pancreatic cancer and their relationship with the clinical pathologic characters.MethodsImmunohistochemistry(SP) was used to detect the expression of CD133 and β-catenin in 35 pancreatic cancer tissues, the cancerous peripheral tissues, the normal pancreatic tissues and peripheral lymphonodes.ResultsThe positive rates of CD133 and β-catenin expression in pancreatic carcinomas which were 74.3% and 62.9%, were significantly higher than that in adjacent normal tissue(P<0.05). The clinicopathological factors including pathologic staging and lymph node metastasis, were demonstrated significantly positive correlations with the expression of CD133 respectively(P<0.05). The expression of β-catenin was associated with lymph node metastasis, pathological grade and histological differentiation, it also significantly correlated with the expression of CD133 (P<0.05). Consequently, the 5-year survival rate of CD133-positive patients was significantly lower than that of CD133-negative patients (P<0.05).ConclusionsAs important moleculars in prancreatic carcinoma stem cell, both CD133 andβ-catenin play important roles in the tumorigenesis, development and metastasis of pancreatic carcinoma.β-catenin may regulate certain functions of pancreatic cancer stem cell by regulatting CD133's expression.Key words: Pancreatic cancer; Cancer stem cells; CD133; β-catenin; Immunohistochemistry" @default.
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- W3150584817 date "2011-04-01" @default.
- W3150584817 modified "2023-09-27" @default.
- W3150584817 title "Expression of CD133 and β-catenin in pancreatic cancer and clinical relevance" @default.
- W3150584817 doi "https://doi.org/10.3877/cma.j.issn.1674-0793.2011.02.007" @default.
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