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- W3150622955 abstract "Due to their anti-inflammatory action, corticosteroids are the reference treatment for brain injuries and many inflammatory diseases. However, the benefits of acute corticotherapy are now being questioned, particularly in the case of acute peripheral vestibulopathies (APV), characterized by a vestibular syndrome composed of sustained spinning vertigo, spontaneous ocular nystagmus and oscillopsia, perceptual-cognitive, posturo-locomotor, and vegetative disorders. We assessed the effectiveness of acute corticotherapy, and the functional role of acute inflammation observed after sudden unilateral vestibular loss.We used the rodent model of unilateral vestibular neurectomy, mimicking the syndrome observed in patients with APV. We treated the animals during the acute phase of the vestibular syndrome, either with placebo or methylprednisolone, an anti-inflammatory corticosteroid. At the cellular level, impacts of methylprednisolone on endogenous plasticity mechanisms were assessed through analysis of cell proliferation and survival, glial reactions, neuron's membrane excitability, and stress marker. At the behavioral level, vestibular and posturo-locomotor functions' recovery were assessed with appropriate qualitative and quantitative evaluations.We observed that acute treatment with methylprednisolone significantly decreases glial reactions, cell proliferation and survival. In addition, stress and excitability markers were significantly impacted by the treatment. Besides, vestibular syndrome's intensity was enhanced, and vestibular compensation delayed under acute methylprednisolone treatment.We show here, for the first time, that acute anti-inflammatory treatment alters the expression of the adaptive plasticity mechanisms in the deafferented vestibular nuclei and generates enhanced and prolonged vestibular and postural deficits. These results strongly suggest a beneficial role for acute endogenous neuroinflammation in vestibular compensation. They open the way to a change in dogma for the treatment and therapeutic management of vestibular patients." @default.
- W3150622955 created "2021-04-13" @default.
- W3150622955 creator A5018693135 @default.
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- W3150622955 creator A5087127901 @default.
- W3150622955 date "2021-08-21" @default.
- W3150622955 modified "2023-10-02" @default.
- W3150622955 title "Breaking a dogma: acute anti-inflammatory treatment alters both post-lesional functional recovery and endogenous adaptive plasticity mechanisms in a rodent model of acute peripheral vestibulopathy" @default.
- W3150622955 cites W1514171677 @default.
- W3150622955 cites W1563590122 @default.
- W3150622955 cites W1594425991 @default.
- W3150622955 cites W1598817329 @default.
- W3150622955 cites W1854494828 @default.
- W3150622955 cites W1858752788 @default.
- W3150622955 cites W1868273134 @default.
- W3150622955 cites W1909552169 @default.
- W3150622955 cites W1970961617 @default.
- W3150622955 cites W1974466946 @default.
- W3150622955 cites W1976239610 @default.
- W3150622955 cites W1976313477 @default.
- W3150622955 cites W1976371997 @default.
- W3150622955 cites W1976662417 @default.
- W3150622955 cites W1978269241 @default.
- W3150622955 cites W1985931504 @default.
- W3150622955 cites W1987149927 @default.
- W3150622955 cites W1987433942 @default.
- W3150622955 cites W1987699463 @default.
- W3150622955 cites W1988591772 @default.
- W3150622955 cites W1990296033 @default.
- W3150622955 cites W1991203538 @default.
- W3150622955 cites W1992212872 @default.
- W3150622955 cites W2008098737 @default.
- W3150622955 cites W2011861117 @default.
- W3150622955 cites W2025837509 @default.
- W3150622955 cites W2026360384 @default.
- W3150622955 cites W2026370575 @default.
- W3150622955 cites W2030648422 @default.
- W3150622955 cites W2031809301 @default.
- W3150622955 cites W2032689918 @default.
- W3150622955 cites W2038755159 @default.
- W3150622955 cites W2041245333 @default.
- W3150622955 cites W2045372221 @default.
- W3150622955 cites W2048319238 @default.
- W3150622955 cites W2049818238 @default.
- W3150622955 cites W2050483503 @default.
- W3150622955 cites W2063900173 @default.
- W3150622955 cites W2072648819 @default.
- W3150622955 cites W2082263677 @default.
- W3150622955 cites W2082828129 @default.
- W3150622955 cites W2088077953 @default.
- W3150622955 cites W2096160341 @default.
- W3150622955 cites W2099030247 @default.
- W3150622955 cites W2103037576 @default.
- W3150622955 cites W2113911442 @default.
- W3150622955 cites W2116063788 @default.
- W3150622955 cites W2120591551 @default.
- W3150622955 cites W2121466553 @default.
- W3150622955 cites W2123926112 @default.
- W3150622955 cites W2126542571 @default.
- W3150622955 cites W2128676313 @default.
- W3150622955 cites W2128859749 @default.
- W3150622955 cites W2128994172 @default.
- W3150622955 cites W2130198578 @default.
- W3150622955 cites W2132417596 @default.
- W3150622955 cites W2136609615 @default.
- W3150622955 cites W2147180300 @default.
- W3150622955 cites W2150642889 @default.
- W3150622955 cites W2150691073 @default.
- W3150622955 cites W2160970340 @default.
- W3150622955 cites W2162302965 @default.
- W3150622955 cites W2164420087 @default.
- W3150622955 cites W2171661590 @default.
- W3150622955 cites W2199236088 @default.
- W3150622955 cites W2232460448 @default.
- W3150622955 cites W2333113140 @default.
- W3150622955 cites W2336545413 @default.
- W3150622955 cites W2401964813 @default.
- W3150622955 cites W2409782105 @default.
- W3150622955 cites W2460997807 @default.
- W3150622955 cites W2507842763 @default.
- W3150622955 cites W2510828140 @default.
- W3150622955 cites W2554390311 @default.
- W3150622955 cites W2570591260 @default.
- W3150622955 cites W2582057000 @default.
- W3150622955 cites W2592011942 @default.
- W3150622955 cites W2602315531 @default.
- W3150622955 cites W2603880818 @default.
- W3150622955 cites W2604952996 @default.
- W3150622955 cites W2605183658 @default.
- W3150622955 cites W2700330585 @default.
- W3150622955 cites W2735527928 @default.
- W3150622955 cites W2738380951 @default.
- W3150622955 cites W2754554955 @default.