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• W3150636514 endingPage "85" @default.
• W3150636514 startingPage "75" @default.
• W3150636514 abstract "Mitotic spindle is a self-assembling macromolecular machine responsible for the faithful segregation of chromosomes during cell division. Assembly of the spindle is believed to be governed by the 'Search & Capture' (S&C) principle in which dynamic microtubules explore space in search of kinetochores while the latter capture microtubules and thus connect chromosomes to the spindle. Due to the stochastic nature of the encounters between kinetochores and microtubules, the time required for incorporating all chromosomes into the spindle is profoundly affected by geometric constraints, such as the size and shape of kinetochores as well as their distribution in space at the onset of spindle assembly. In recent years, several molecular mechanisms that control these parameters have been discovered. It is now clear that stochastic S&C takes place in structured space, where components are optimally distributed and oriented to minimize steric hindrances. Nucleation of numerous non-centrosomal microtubules near kinetochores accelerates capture, while changes in the kinetochore architecture at various stages of spindle assembly promote proper connection of sister kinetochores to the opposite spindle poles. Here we discuss how the concerted action of multiple facilitating mechanisms ensure that the spindle assembles rapidly yet with a minimal number of errors." @default.
• W3150636514 created "2021-04-13" @default.
• W3150636514 creator A5016812837 @default.
• W3150636514 creator A5073934674 @default.
• W3150636514 date "2021-09-01" @default.
• W3150636514 modified "2023-09-24" @default.
• W3150636514 title "Role of spatial patterns and kinetochore architecture in spindle morphogenesis" @default.
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