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- W3150653407 abstract "Aim:To investigate the role of histamine in memory deficits induced by MK-801 infusion into the ventral hippocampus in rats.Methods:An 8-arm radial maze(4 arms baited)was used to assess spatial memory.Results:Bilateral ventral intrahippocampal(ih)infusion of MK-801(0.3 μg/site),an N-methyl-D-aspartate (NMDA)antagonist,impaired the retrieval process in both working memory and reference memory.Intrahippocampal injection of histamine(25 or 50 ng/site)or intraperitoneal(ip)injection of histidine(25,50 or 100 mg/kg)markedly amelio- rated the spatial memory deficits induced by MK-801.Both the histamine H_1 an- tagonist pyrilamine(0.5 or 1.0 μg/site,ih)and the H2 antagonist cimetidine(2.5 μg/site, ih)abolished the ameliorating effect of histidine( 100 mg/kg,ip)on reference memory deficits,but not that on working memory deficits induced by MK-801.Conclusion: The results indicate that histamine in the ventral hippocampus can ameliorate MK-801-induced spatial memory deficits,and that histamine's effect on reference memory is mediated by postsynaptic histamine H_1 and H_2 receptors." @default.
- W3150653407 created "2021-04-13" @default.
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- W3150653407 date "2005-01-01" @default.
- W3150653407 modified "2023-09-23" @default.
- W3150653407 title "Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats" @default.
- W3150653407 hasPublicationYear "2005" @default.
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