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- W3150661421 endingPage "111278" @default.
- W3150661421 startingPage "111278" @default.
- W3150661421 abstract "Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has emerged as an adipokine more than fifteen years ago, integrating the field of inter-organs interactions. The apelin/APJ system plays important roles in several physiological functions both in rodent and humans such as fluid homeostasis, cardiovascular physiology, angiogenesis, energy metabolism. Thus the apelin/APJ system has generated great interest as a potential therapeutic target in different pathologies. The present review will consider the effects of apelin in metabolic diseases such as obesity and diabetes with a focus on diabetic cardiomyopathy among the complications associated with diabetes and APJ agonists or antagonists of interest in these diseases." @default.
- W3150661421 created "2021-04-13" @default.
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- W3150661421 creator A5048531337 @default.
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- W3150661421 date "2021-06-01" @default.
- W3150661421 modified "2023-10-04" @default.
- W3150661421 title "The therapeutic potentials of apelin in obesity-associated diseases" @default.
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- W3150661421 doi "https://doi.org/10.1016/j.mce.2021.111278" @default.
- W3150661421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33838166" @default.
- W3150661421 hasPublicationYear "2021" @default.
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