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- W3150704956 abstract "Background Objectives:The clinical study showed that the P glycoprotein(P gp) expression was closely associated with the chemotherapeutic effect, response rate, prognosis, and survival time. Until now, few clinical papers have reported about metastatic sites and its response to chemotherapy with P gp expression in metastatic breast carcinoma. The current study was designed to investigate the role of P gp expression and its clinical value of chemotherapy for the patients with different metastatic sites of this carcinoma. Methods: P gp expression in 46 postoperative patients with metastatic breast carcinoma was detected by SABC immunohistochemical method. 43 cases treated with combination regimen: Cyclophosphamide 600 mg/m2 iv on day 1, Pirarubicin 60 mg/m2 iv on day 1, 5 Fluorouracil 600 mg/m2 iv on days 1 and 8. Repeat the cycle every 3 weeks for at least 2 cycles. The correlation between P gp expression and chemotherapeutic response was analyzed. Results:1) P gp expression positive rate was 56 5%, the P gp expression in the patients with lung or liver viscera metastasis was higher than that in skin or lymph node metastasis (P=0 049). 2)The overall response rate was 58 1%in 43 patients.The response rate of the P gp negative group was higher than the P gp positive group(P 0 01). 3) The response rate in the patients with skin and lymph node metastasis was higher than the patients with lung and liver metastasis (P 0 05). 4)The postoperative patients who had received CAF(cyclophosphamide+adriamycin+5 fluorouracil) or CMF(cyclophosphamide+methotrexate+5 fluorouracil) regimen adjuvant chemotherapy previously, the response rate of metastatic diseases to chemotherapy had no significant difference (P 0 05). Conclusions:P gp expression may be considered as an index for evaluating multidrug resistance, guiding drug use, and judging prognosis of the patients with metastatic breast carcinoma." @default.
- W3150704956 created "2021-04-13" @default.
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- W3150704956 date "2002-01-01" @default.
- W3150704956 modified "2023-09-25" @default.
- W3150704956 title "Influence of P-glycoprotein Expression on ChemotherapeuticResponse of Metastatic Breast Carcinoma" @default.
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