Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150752017> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3150752017 endingPage "326" @default.
- W3150752017 startingPage "318" @default.
- W3150752017 abstract "尽管组成的原子因素(NF )-kappaB 激活在许多人的肿瘤被报导了，在食道的有鳞的房间癌(ESCC ) 的 NF-kappaB 小径的角色没被知道。在这研究，在二根 ESCC 房间线的 NF-kappaB 小径用免疫细胞化学，西方的污点和反向的抄写聚合酶链被调查反应。NF-kappaB DNA 绑定的激活被 electrophoretic 活动性移动试金决定。RNA 干扰被用来明确地禁止 p65 的表示。房间的生长被 3-(4,5-dimethylthiazol-2-yl ) 评估 -2,5-diphenyltetrazolium 溴化物试金。结果证明 p50， p65， IkappaBalpha p-IkappaBalpha 和 IkappaB kinase 贝它被表示并且在细胞质主要局部性。反向的抄写聚合酶链反应结果在二根 ESCC 房间线显示出 p50， p65 和 IkappaBalpha mRNA 的组成的表情。而且，原子摘录表明到原子核的 p50 和 p65 translocated 举办了 DNA 有约束力的活动。最后， p65 的小介入 RNA 减少了 p65 的表示，和有 p65 的房间 transfected 的生存能力小介入 RNA 显著地在 5 氟尿嘧啶的一样的集中被压制(P < 0.05 ) 与 untransfected 房间相比。这研究的结果证明有在 ESCC 房间线表明小径的组成地激活的 NF-kB。在 p65 指向的 RNA 干扰增加了 ESCC 房间线的敏感到 5 氟尿嘧啶，建议 NF-kappaB 可能是为癌症治疗的一个好目标。" @default.
- W3150752017 created "2021-04-13" @default.
- W3150752017 creator A5006579524 @default.
- W3150752017 creator A5007659853 @default.
- W3150752017 creator A5014610147 @default.
- W3150752017 creator A5025879011 @default.
- W3150752017 creator A5046265700 @default.
- W3150752017 creator A5046389053 @default.
- W3150752017 creator A5065468312 @default.
- W3150752017 creator A5075993034 @default.
- W3150752017 creator A5080536627 @default.
- W3150752017 creator A5086410846 @default.
- W3150752017 date "2006-01-01" @default.
- W3150752017 modified "2023-09-23" @default.
- W3150752017 title "Nuclear Factor-kB Signaling Pathway Constitutively Activated in Esophageal Squamous Cell Carcinoma Cell Lines and Inhibition of Growth of Cells by Small Interfering RNA" @default.
- W3150752017 hasPublicationYear "2006" @default.
- W3150752017 type Work @default.
- W3150752017 sameAs 3150752017 @default.
- W3150752017 citedByCount "0" @default.
- W3150752017 crossrefType "journal-article" @default.
- W3150752017 hasAuthorship W3150752017A5006579524 @default.
- W3150752017 hasAuthorship W3150752017A5007659853 @default.
- W3150752017 hasAuthorship W3150752017A5014610147 @default.
- W3150752017 hasAuthorship W3150752017A5025879011 @default.
- W3150752017 hasAuthorship W3150752017A5046265700 @default.
- W3150752017 hasAuthorship W3150752017A5046389053 @default.
- W3150752017 hasAuthorship W3150752017A5065468312 @default.
- W3150752017 hasAuthorship W3150752017A5075993034 @default.
- W3150752017 hasAuthorship W3150752017A5080536627 @default.
- W3150752017 hasAuthorship W3150752017A5086410846 @default.
- W3150752017 hasConcept C104317684 @default.
- W3150752017 hasConcept C105580179 @default.
- W3150752017 hasConcept C153911025 @default.
- W3150752017 hasConcept C166703698 @default.
- W3150752017 hasConcept C22615655 @default.
- W3150752017 hasConcept C502942594 @default.
- W3150752017 hasConcept C54009773 @default.
- W3150752017 hasConcept C54355233 @default.
- W3150752017 hasConcept C67705224 @default.
- W3150752017 hasConcept C81885089 @default.
- W3150752017 hasConcept C86339819 @default.
- W3150752017 hasConcept C86803240 @default.
- W3150752017 hasConcept C95444343 @default.
- W3150752017 hasConcept C98270193 @default.
- W3150752017 hasConceptScore W3150752017C104317684 @default.
- W3150752017 hasConceptScore W3150752017C105580179 @default.
- W3150752017 hasConceptScore W3150752017C153911025 @default.
- W3150752017 hasConceptScore W3150752017C166703698 @default.
- W3150752017 hasConceptScore W3150752017C22615655 @default.
- W3150752017 hasConceptScore W3150752017C502942594 @default.
- W3150752017 hasConceptScore W3150752017C54009773 @default.
- W3150752017 hasConceptScore W3150752017C54355233 @default.
- W3150752017 hasConceptScore W3150752017C67705224 @default.
- W3150752017 hasConceptScore W3150752017C81885089 @default.
- W3150752017 hasConceptScore W3150752017C86339819 @default.
- W3150752017 hasConceptScore W3150752017C86803240 @default.
- W3150752017 hasConceptScore W3150752017C95444343 @default.
- W3150752017 hasConceptScore W3150752017C98270193 @default.
- W3150752017 hasIssue "5" @default.
- W3150752017 hasLocation W31507520171 @default.
- W3150752017 hasOpenAccess W3150752017 @default.
- W3150752017 hasPrimaryLocation W31507520171 @default.
- W3150752017 hasRelatedWork W1223174617 @default.
- W3150752017 hasRelatedWork W139837180 @default.
- W3150752017 hasRelatedWork W1980934717 @default.
- W3150752017 hasRelatedWork W2012604612 @default.
- W3150752017 hasRelatedWork W2046588575 @default.
- W3150752017 hasRelatedWork W2067998079 @default.
- W3150752017 hasRelatedWork W2076350014 @default.
- W3150752017 hasRelatedWork W2090123783 @default.
- W3150752017 hasRelatedWork W2127172249 @default.
- W3150752017 hasRelatedWork W2131913085 @default.
- W3150752017 hasRelatedWork W2148951315 @default.
- W3150752017 hasRelatedWork W2153756804 @default.
- W3150752017 hasRelatedWork W2268953472 @default.
- W3150752017 hasRelatedWork W2301126315 @default.
- W3150752017 hasRelatedWork W2372186921 @default.
- W3150752017 hasRelatedWork W2420514583 @default.
- W3150752017 hasRelatedWork W3016333653 @default.
- W3150752017 hasRelatedWork W3018549703 @default.
- W3150752017 hasRelatedWork W3144751490 @default.
- W3150752017 hasRelatedWork W2473021825 @default.
- W3150752017 hasVolume "38" @default.
- W3150752017 isParatext "false" @default.
- W3150752017 isRetracted "false" @default.
- W3150752017 magId "3150752017" @default.
- W3150752017 workType "article" @default.