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- W3150761511 abstract "Objective Investigate the effect of selenite and arsenic on antioxidant enzymes activities in tis- sties and that of selenite antagonism toward arsenic. Methods Human fetal lung (HFL ) tissues were exposed to diverse concentrations of As2O3 and Na2SeO3. Then its activities of antioxidant enzymes GSH-Px,CAT,Mn-SOD and total SOD were measured. Results 30, 50, 100μmol/L arsenic significantly decreased the activities of 4 kinds of enzymes. On the contrary,GSH-Px and CAT activities of HFL tissues were markedly raised by supplementa- tion of 0.1, 1.0μmol/L Na2SeO3. The inhibition of 4 kinds of antioxidant enzymes activities caused by 30, 50μmol/L As2O3 could be significantly improved by pretreatment with 0.1, 1.0μmol/L Na2SeO3;Na2SeO3 had no effect on the inhibition of antioxidant enzymes activities caused by 100μmol/L As2O3; 10μmol/L Na2SeO3 preincubation with each concentration of As2O3 had a synergistic toxicity. Conclusions Appropriate dosage selenite can antagonize arsenic that induced inhibition of antioxidant enzymes activities. It will provide clues for selenium as a preventive agent to arsenic poison." @default.
- W3150761511 created "2021-04-13" @default.
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- W3150761511 date "2000-01-01" @default.
- W3150761511 modified "2023-09-27" @default.
- W3150761511 title "Effect of selenite antagonism to arsenic-induced inhibition of antioxidant enzymes activities in human fetal lung tissues in vitro" @default.
- W3150761511 hasPublicationYear "2000" @default.
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