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• W3150775225 abstract "Exosomes (Exos) are nanosized vesicles (around 100 nm) that recently serve as a promising drug carrier with high biocompatibility and low immunogenicity. Previous studies showed that Exos secreted from mesenchymal stem cells (MSCs) provide protection for concanavalin A (Con A)-induced liver injury. In this study, the protective effect of Exos is confirmed, and dexamethasone (DEX)-incorporated Exos named Exo@DEX are prepared. It is then investigated whether Exo@DEX can function more efficiently compared to free drugs and naive Exos in a Con A-induced autoimmune hepatitis (AIH) mouse model. The results show that Exo@DEX efficiently improves the accumulation of DEX in AIH in the liver. These data suggest that Exo@DEX is a promising drug carrier for AIH and could have applications in other diseases." @default.
• W3150775225 created "2021-04-13" @default.
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• W3150775225 date "2021-03-30" @default.
• W3150775225 modified "2023-10-07" @default.
• W3150775225 title "Mesenchymal Stem Cells-Derived Exosomes as Dexamethasone Delivery Vehicles for Autoimmune Hepatitis Therapy" @default.
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• W3150775225 doi "https://doi.org/10.3389/fbioe.2021.650376" @default.
• W3150775225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8042336" @default.
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