Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150778881> ?p ?o ?g. }
- W3150778881 abstract "Leptin has been shown to play a crucial role in the regulation of body weight. There is also evidence that this adipokine plays a key role in the process of osteoar- thritis. However, the precise role of leptin on articular cartilage metabolism is not clear. We investigate the role of leptin on articular cartilage in vivo in this study. Recom- binant rat leptin (100 lg) was injected into the knee joints of rats, 48 h later, messenger RNA (mRNA) expression and protein levels of basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), cathepsin D, and collagen II from articular cartilage were analyzed by real-time quantitative polymerase chain reaction (PCR) and western blot. Two important aggrecanases ADAMTS-4 and -5 (a disintegrin and metalloproteinase with thrombo- spondin motifs 4 and 5) were also analyzed by real-time quantitative PCR. Besides, articular cartilage was also assessed for proteoglycan/GAG content by Safranin O staining. Leptin significantly increased both gene and protein levels of MMP-2, MMP-9, cathepsin D, and col- lagen II, while decreased bFGF markedly in cartilage. Moreover, the gene expression of ADAMTS-4 and -5 were markedly increased, and histologically assessed depletion of proteoglycan in articular cartilage was observed after treatment with leptin. These results strongly suggest that leptin plays a catabolic role on cartilage metabolism and may be a disadvantage factor involve in the pathological process of OA." @default.
- W3150778881 created "2021-04-13" @default.
- W3150778881 creator A5014368837 @default.
- W3150778881 creator A5024118357 @default.
- W3150778881 creator A5046423894 @default.
- W3150778881 creator A5088309411 @default.
- W3150778881 date "2010-01-01" @default.
- W3150778881 modified "2023-09-29" @default.
- W3150778881 title "Leptin plays a catabolic role on articular cartilage" @default.
- W3150778881 cites W11305555 @default.
- W3150778881 cites W123379006 @default.
- W3150778881 cites W1493844743 @default.
- W3150778881 cites W1594976448 @default.
- W3150778881 cites W1712774648 @default.
- W3150778881 cites W1772675489 @default.
- W3150778881 cites W1894541755 @default.
- W3150778881 cites W1972496457 @default.
- W3150778881 cites W1972783122 @default.
- W3150778881 cites W1977568667 @default.
- W3150778881 cites W1983838735 @default.
- W3150778881 cites W1985475058 @default.
- W3150778881 cites W1985589632 @default.
- W3150778881 cites W1996713062 @default.
- W3150778881 cites W2010109615 @default.
- W3150778881 cites W2010837855 @default.
- W3150778881 cites W2016189767 @default.
- W3150778881 cites W2022494133 @default.
- W3150778881 cites W2023251607 @default.
- W3150778881 cites W2023282468 @default.
- W3150778881 cites W2023560282 @default.
- W3150778881 cites W2025846514 @default.
- W3150778881 cites W2033916067 @default.
- W3150778881 cites W2034919108 @default.
- W3150778881 cites W2035105700 @default.
- W3150778881 cites W2037270622 @default.
- W3150778881 cites W2045392251 @default.
- W3150778881 cites W2050993701 @default.
- W3150778881 cites W2052765222 @default.
- W3150778881 cites W2053628893 @default.
- W3150778881 cites W2059624503 @default.
- W3150778881 cites W2060871317 @default.
- W3150778881 cites W2070361364 @default.
- W3150778881 cites W2070393006 @default.
- W3150778881 cites W2072655277 @default.
- W3150778881 cites W2077559627 @default.
- W3150778881 cites W2078752434 @default.
- W3150778881 cites W2081876438 @default.
- W3150778881 cites W2086569993 @default.
- W3150778881 cites W2086908525 @default.
- W3150778881 cites W2089526417 @default.
- W3150778881 cites W2091087465 @default.
- W3150778881 cites W2094544818 @default.
- W3150778881 cites W2096834315 @default.
- W3150778881 cites W2100937354 @default.
- W3150778881 cites W2106862840 @default.
- W3150778881 cites W2109658199 @default.
- W3150778881 cites W2113905699 @default.
- W3150778881 cites W2120840387 @default.
- W3150778881 cites W2130200649 @default.
- W3150778881 cites W2130728604 @default.
- W3150778881 cites W2135197803 @default.
- W3150778881 cites W2137736712 @default.
- W3150778881 cites W2148662297 @default.
- W3150778881 cites W2151305143 @default.
- W3150778881 cites W2155361429 @default.
- W3150778881 cites W2166756374 @default.
- W3150778881 cites W2167869180 @default.
- W3150778881 cites W2170651748 @default.
- W3150778881 cites W2411853326 @default.
- W3150778881 hasPublicationYear "2010" @default.
- W3150778881 type Work @default.
- W3150778881 sameAs 3150778881 @default.
- W3150778881 citedByCount "84" @default.
- W3150778881 countsByYear W31507788812012 @default.
- W3150778881 countsByYear W31507788812013 @default.
- W3150778881 countsByYear W31507788812014 @default.
- W3150778881 countsByYear W31507788812015 @default.
- W3150778881 countsByYear W31507788812016 @default.
- W3150778881 countsByYear W31507788812017 @default.
- W3150778881 countsByYear W31507788812018 @default.
- W3150778881 countsByYear W31507788812019 @default.
- W3150778881 countsByYear W31507788812020 @default.
- W3150778881 countsByYear W31507788812021 @default.
- W3150778881 countsByYear W31507788812022 @default.
- W3150778881 countsByYear W31507788812023 @default.
- W3150778881 crossrefType "journal-article" @default.
- W3150778881 hasAuthorship W3150778881A5014368837 @default.
- W3150778881 hasAuthorship W3150778881A5024118357 @default.
- W3150778881 hasAuthorship W3150778881A5046423894 @default.
- W3150778881 hasAuthorship W3150778881A5088309411 @default.
- W3150778881 hasConcept C105702510 @default.
- W3150778881 hasConcept C126322002 @default.
- W3150778881 hasConcept C134018914 @default.
- W3150778881 hasConcept C142724271 @default.
- W3150778881 hasConcept C167844969 @default.
- W3150778881 hasConcept C181199279 @default.
- W3150778881 hasConcept C185592680 @default.
- W3150778881 hasConcept C194832188 @default.
- W3150778881 hasConcept C197534660 @default.
- W3150778881 hasConcept C204787440 @default.