Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150783208> ?p ?o ?g. }
- W3150783208 abstract "Abstract Numerous substrates have been identified for Type I and II arginine methyltransferases (PRMTs). However, the full substrate spectrum of the only type III PRMT, PRMT7, and its connection to type I and II PRMT substrates remains unknown. Here, we use mass spectrometry to reveal features of PRMT7-regulated methylation. We find that PRMT7 predominantly methylates a glycine and arginine motif; multiple PRMT7-regulated arginine methylation sites are close to phosphorylations sites; methylation sites and proximal sequences are vulnerable to cancer mutations; and methylation is enriched in proteins associated with spliceosome and RNA-related pathways. We show that PRMT4/5/7-mediated arginine methylation regulates hnRNPA1 binding to RNA and several alternative splicing events. In breast, colorectal and prostate cancer cells, PRMT4/5/7 are upregulated and associated with high levels of hnRNPA1 arginine methylation and aberrant alternative splicing. Pharmacological inhibition of PRMT4/5/7 suppresses cancer cell growth and their co-inhibition shows synergistic effects, suggesting them as targets for cancer therapy." @default.
- W3150783208 created "2021-04-13" @default.
- W3150783208 creator A5001969147 @default.
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- W3150783208 creator A5088239676 @default.
- W3150783208 date "2021-03-29" @default.
- W3150783208 modified "2023-10-03" @default.
- W3150783208 title "Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth" @default.
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