Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150804929> ?p ?o ?g. }
- W3150804929 abstract "Abstract Thyroid hormone analogues—particularly, l -thyroxine (T 4 ) has been shown to be relevant to the functions of a variety of cancers. Integrin αvβ3 is a plasma membrane structural protein linked to signal transduction pathways that are critical to cancer cell proliferation and metastasis. Thyroid hormones, T 4 and to a less extend T 3 bind cell surface integrin αvβ3, to stimulate the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway to stimulate cancer cell growth. Thyroid hormone analogues also engage in crosstalk with the epidermal growth factor receptor (EGFR)-Ras pathway. EGFR signal generation and, downstream, transduction of Ras/Raf pathway signals contribute importantly to tumor cell progression. Mutated Ras oncogenes contribute to chemoresistance in colorectal carcinoma (CRC); chemoresistance may depend in part on the activity of ERK1/2 pathway. In this review, we evaluate the contribution of thyroxine interacting with integrin αvβ3 and crosstalking with EGFR/Ras signaling pathway non-genomically in CRC proliferation. Tetraiodothyroacetic acid (tetrac), the deaminated analogue of T 4 , and its nano-derivative, NDAT, have anticancer functions, with effectiveness against CRC and other tumors. In Ras -mutant CRC cells, tetrac derivatives may overcome chemoresistance to other drugs via actions initiated at integrin αvβ3 and involving, downstream, the EGFR-Ras signaling pathways." @default.
- W3150804929 created "2021-04-13" @default.
- W3150804929 creator A5010634066 @default.
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- W3150804929 creator A5052596733 @default.
- W3150804929 creator A5064680897 @default.
- W3150804929 creator A5067104122 @default.
- W3150804929 creator A5067497938 @default.
- W3150804929 date "2021-04-08" @default.
- W3150804929 modified "2023-10-14" @default.
- W3150804929 title "Role of thyroid hormone-integrin αvβ3-signal and therapeutic strategies in colorectal cancers" @default.
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