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- W3150831331 abstract "AIM To investigate whether the proportions of acetylhistone-positive hepatocytes could be used as markersof deteriorating liver function.METHODS： In total, 611 cirrhotic cases from 3701patients who were diagnosed during the past 15years were screened, and 152 follow-up cases wereselected. Paraffin tissue microarray was preparedfor immunohistochemistry to examine acetyl-histoneexpression. The proportions of positive hepatocyteswere recorded, and their correlations to clinical andlaboratory indicators were analyzed statistically.RESULTS： The proportions of H2AK5ac＋, H3K9/K14ac＋and H3K27ac＋ hepatocytes gradually increased withdeteriorating liver function and with increasing levelsof serum markers of liver injury. In the follow-upcases, patients with 〉 70% H2AK5ac＋, H3K9/K14ac＋ orH3K27ac＋ hepatocytes had statistically lower survivalrates （P 〈 0.05）. Furthermore, 〉 70% H2AK5ac＋or H3K27ac＋ hepatocytes were strong independentpredictors of overall survival （P 〈 0.05）.CONCLUSION： The proportions of acetyl-histonepositivehepatocytes are closely associated with theliver function and prognosis of cirrhotic patients." @default.
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- W3150831331 date "2015-01-01" @default.
- W3150831331 modified "2023-09-26" @default.
- W3150831331 title "Proportions of acetyl-histone-positive hepatocytes indicatethe functional status and prognosis of cirrhotic patients" @default.
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