FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150831337> ?p ?o ?g. }

• W3150831337 endingPage "3" @default.
• W3150831337 startingPage "3" @default.
• W3150831337 abstract ": In childhood immune thrombocytopenia (ITP), the morbidity is significant due to the risk of bleeding and a reduced health-related quality of life (HRQoL). Current management guidelines indicate that treatment is considered for children with moderate to severe bleeding, or a reduced HRQoL. Intravenous immunoglobulin (IVIg) treatment has been introduced in childhood ITP in 1981. IVIg treatment speeds up the remission of thrombocytopenia in newly diagnosed ITP and reduces bleeding symptoms, but this has the disadvantage of side effects and costs. Some data indicated that IVIg may modulate the late disease outcomes of ITP, but our recent randomized controlled trial (RCT) showed that IVIg does not affect the development of chronic ITP. Overall, 60% of children with newly diagnosed ITP show a sustained response to IVIg. Such a sustained response after IVIg treatment is strongly associated with long-term remission from ITP. Recent molecular and clinical data show that treatment responders could be identified before IVIg is administered. The same molecular and clinical characteristics that identify treatment responders are otherwise associated with a transient, self-limiting ITP disease course, suggesting the identification of a distinct subgroup of ITP patients. Thus, the development of multivariate clinical and molecular prediction scores could allow to individualize treatment decisions, i.e., target IVIg to those who benefit the most. These prediction scores may also be used to design studies aimed at identifying children who benefit from adjunctive or alternative treatments, such as thrombopoietin receptor agonists (TPO-Ra)." @default.
• W3150831337 created "2021-04-13" @default.
• W3150831337 creator A5030139116 @default.
• W3150831337 creator A5030808557 @default.
• W3150831337 creator A5052575656 @default.
• W3150831337 creator A5074307769 @default.
• W3150831337 date "2021-03-01" @default.
• W3150831337 modified "2023-09-25" @default.
• W3150831337 title "Intravenous immunoglobulins (IVIg) in childhood immune thrombocytopenia: towards personalized medicine—a narrative review" @default.
• W3150831337 cites W1489726069 @default.
• W3150831337 cites W1495224833 @default.
• W3150831337 cites W1512739303 @default.
• W3150831337 cites W1566390556 @default.
• W3150831337 cites W1964180982 @default.
• W3150831337 cites W1969566297 @default.
• W3150831337 cites W1974558207 @default.
• W3150831337 cites W1974829928 @default.
• W3150831337 cites W1979791879 @default.
• W3150831337 cites W1984073642 @default.
• W3150831337 cites W1985240611 @default.
• W3150831337 cites W1994592508 @default.
• W3150831337 cites W2003391236 @default.
• W3150831337 cites W2008743038 @default.
• W3150831337 cites W2010320354 @default.
• W3150831337 cites W2013148460 @default.
• W3150831337 cites W2016934054 @default.
• W3150831337 cites W2024505041 @default.
• W3150831337 cites W2025522212 @default.
• W3150831337 cites W2031284084 @default.
• W3150831337 cites W2057948390 @default.
• W3150831337 cites W2059190713 @default.
• W3150831337 cites W2069858985 @default.
• W3150831337 cites W2072577743 @default.
• W3150831337 cites W2084469556 @default.
• W3150831337 cites W2085861328 @default.
• W3150831337 cites W2086104998 @default.
• W3150831337 cites W2087777738 @default.
• W3150831337 cites W2093149203 @default.
• W3150831337 cites W2094655231 @default.
• W3150831337 cites W2099437600 @default.
• W3150831337 cites W2104678503 @default.
• W3150831337 cites W2115471441 @default.
• W3150831337 cites W2115876636 @default.
• W3150831337 cites W2116547757 @default.
• W3150831337 cites W2117761540 @default.
• W3150831337 cites W2121787952 @default.
• W3150831337 cites W2129635768 @default.
• W3150831337 cites W2130672995 @default.
• W3150831337 cites W2140903638 @default.
• W3150831337 cites W2151324717 @default.
• W3150831337 cites W2163543567 @default.
• W3150831337 cites W2744910424 @default.
• W3150831337 cites W2778963731 @default.
• W3150831337 cites W2782418845 @default.
• W3150831337 cites W2795205449 @default.
• W3150831337 cites W2911123429 @default.
• W3150831337 cites W2955445077 @default.
• W3150831337 cites W3005547305 @default.
• W3150831337 cites W3093024516 @default.
• W3150831337 cites W92943800 @default.
• W3150831337 cites W2040726867 @default.
• W3150831337 cites W2048486696 @default.
• W3150831337 cites W2161967961 @default.
• W3150831337 doi "https://doi.org/10.21037/aob-20-59" @default.
• W3150831337 hasPublicationYear "2021" @default.
• W3150831337 type Work @default.
• W3150831337 sameAs 3150831337 @default.
• W3150831337 citedByCount "2" @default.
• W3150831337 countsByYear W31508313372021 @default.
• W3150831337 crossrefType "journal-article" @default.
• W3150831337 hasAuthorship W3150831337A5030139116 @default.
• W3150831337 hasAuthorship W3150831337A5030808557 @default.
• W3150831337 hasAuthorship W3150831337A5052575656 @default.
• W3150831337 hasAuthorship W3150831337A5074307769 @default.
• W3150831337 hasBestOaLocation W31508313371 @default.
• W3150831337 hasConcept C126322002 @default.
• W3150831337 hasConcept C159110408 @default.
• W3150831337 hasConcept C159654299 @default.
• W3150831337 hasConcept C168563851 @default.
• W3150831337 hasConcept C187212893 @default.
• W3150831337 hasConcept C203014093 @default.
• W3150831337 hasConcept C2779134260 @default.
• W3150831337 hasConcept C2779951463 @default.
• W3150831337 hasConcept C2993327898 @default.
• W3150831337 hasConcept C535046627 @default.
• W3150831337 hasConcept C71924100 @default.
• W3150831337 hasConceptScore W3150831337C126322002 @default.
• W3150831337 hasConceptScore W3150831337C159110408 @default.
• W3150831337 hasConceptScore W3150831337C159654299 @default.
• W3150831337 hasConceptScore W3150831337C168563851 @default.
• W3150831337 hasConceptScore W3150831337C187212893 @default.
• W3150831337 hasConceptScore W3150831337C203014093 @default.
• W3150831337 hasConceptScore W3150831337C2779134260 @default.
• W3150831337 hasConceptScore W3150831337C2779951463 @default.
• W3150831337 hasConceptScore W3150831337C2993327898 @default.
• W3150831337 hasConceptScore W3150831337C535046627 @default.
• W3150831337 hasConceptScore W3150831337C71924100 @default.
• W3150831337 hasLocation W31508313371 @default.

• next