FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150870868> ?p ?o ?g. }

• W3150870868 endingPage "367" @default.
• W3150870868 startingPage "361" @default.
• W3150870868 abstract "The present study was designed to determine the effects of Guanfu base A(GFA) on the late sodium current(INa.L),transient sodium current(INa.T),HERG current(IHERG),and Kv1.5 current(IKv1.5).The values of INa.L,INa.T,IHERG and IKv1.5 were recorded using the whole-cell patch clamp technique.Compared with other channels,GFA showed selective blocking activity in late sodium channel.It inhibited INa.L in a concentration-dependent manner with an IC50 of(1.57 ± 0.14) μmol·L-1,which was significantly lower than its IC50 values of(21.17 ± 4.51) μmol·L-1 for the INa.T.The inhibitory effect of GFA on INa,L was not affected by 200μmol·L-1 H2O2.It inhibited IHERG with an IC50 of(273 ± 34) μmol·L-1 and has slight blocking effect on IKv1.5,decreasing IKv1.5 by only 20.6% at 200 μmol·L-1.In summary,GFA inhibited INa.L selectively and remained similar inhibition in presence of reactive oxygen species..These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders." @default.
• W3150870868 created "2021-04-13" @default.
• W3150870868 creator A5001991575 @default.
• W3150870868 creator A5002522499 @default.
• W3150870868 creator A5022012246 @default.
• W3150870868 creator A5022944427 @default.
• W3150870868 creator A5025879011 @default.
• W3150870868 creator A5028615584 @default.
• W3150870868 creator A5051552423 @default.
• W3150870868 creator A5064289650 @default.
• W3150870868 creator A5066562642 @default.
• W3150870868 creator A5070913496 @default.
• W3150870868 creator A5079842099 @default.
• W3150870868 creator A5086621213 @default.
• W3150870868 date "2015-01-01" @default.
• W3150870868 modified "2023-09-23" @default.
• W3150870868 title "Antiarrhythmic ionic mechanism of Guanfu base A Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs" @default.
• W3150870868 hasPublicationYear "2015" @default.
• W3150870868 type Work @default.
• W3150870868 sameAs 3150870868 @default.
• W3150870868 citedByCount "0" @default.
• W3150870868 crossrefType "journal-article" @default.
• W3150870868 hasAuthorship W3150870868A5001991575 @default.
• W3150870868 hasAuthorship W3150870868A5002522499 @default.
• W3150870868 hasAuthorship W3150870868A5022012246 @default.
• W3150870868 hasAuthorship W3150870868A5022944427 @default.
• W3150870868 hasAuthorship W3150870868A5025879011 @default.
• W3150870868 hasAuthorship W3150870868A5028615584 @default.
• W3150870868 hasAuthorship W3150870868A5051552423 @default.
• W3150870868 hasAuthorship W3150870868A5064289650 @default.
• W3150870868 hasAuthorship W3150870868A5066562642 @default.
• W3150870868 hasAuthorship W3150870868A5070913496 @default.
• W3150870868 hasAuthorship W3150870868A5079842099 @default.
• W3150870868 hasAuthorship W3150870868A5086621213 @default.
• W3150870868 hasConcept C12554922 @default.
• W3150870868 hasConcept C134018914 @default.
• W3150870868 hasConcept C138496976 @default.
• W3150870868 hasConcept C147944092 @default.
• W3150870868 hasConcept C15744967 @default.
• W3150870868 hasConcept C170493617 @default.
• W3150870868 hasConcept C17077164 @default.
• W3150870868 hasConcept C178790620 @default.
• W3150870868 hasConcept C185592680 @default.
• W3150870868 hasConcept C202751555 @default.
• W3150870868 hasConcept C23186085 @default.
• W3150870868 hasConcept C2777752497 @default.
• W3150870868 hasConcept C2778815084 @default.
• W3150870868 hasConcept C2779362680 @default.
• W3150870868 hasConcept C50952357 @default.
• W3150870868 hasConcept C537181965 @default.
• W3150870868 hasConcept C55493867 @default.
• W3150870868 hasConcept C83743174 @default.
• W3150870868 hasConcept C86803240 @default.
• W3150870868 hasConcept C98274493 @default.
• W3150870868 hasConceptScore W3150870868C12554922 @default.
• W3150870868 hasConceptScore W3150870868C134018914 @default.
• W3150870868 hasConceptScore W3150870868C138496976 @default.
• W3150870868 hasConceptScore W3150870868C147944092 @default.
• W3150870868 hasConceptScore W3150870868C15744967 @default.
• W3150870868 hasConceptScore W3150870868C170493617 @default.
• W3150870868 hasConceptScore W3150870868C17077164 @default.
• W3150870868 hasConceptScore W3150870868C178790620 @default.
• W3150870868 hasConceptScore W3150870868C185592680 @default.
• W3150870868 hasConceptScore W3150870868C202751555 @default.
• W3150870868 hasConceptScore W3150870868C23186085 @default.
• W3150870868 hasConceptScore W3150870868C2777752497 @default.
• W3150870868 hasConceptScore W3150870868C2778815084 @default.
• W3150870868 hasConceptScore W3150870868C2779362680 @default.
• W3150870868 hasConceptScore W3150870868C50952357 @default.
• W3150870868 hasConceptScore W3150870868C537181965 @default.
• W3150870868 hasConceptScore W3150870868C55493867 @default.
• W3150870868 hasConceptScore W3150870868C83743174 @default.
• W3150870868 hasConceptScore W3150870868C86803240 @default.
• W3150870868 hasConceptScore W3150870868C98274493 @default.
• W3150870868 hasIssue "5" @default.
• W3150870868 hasLocation W31508708681 @default.
• W3150870868 hasOpenAccess W3150870868 @default.
• W3150870868 hasPrimaryLocation W31508708681 @default.
• W3150870868 hasRelatedWork W110863162 @default.
• W3150870868 hasRelatedWork W1576249857 @default.
• W3150870868 hasRelatedWork W2075514718 @default.
• W3150870868 hasRelatedWork W2257496536 @default.
• W3150870868 hasRelatedWork W2348033198 @default.
• W3150870868 hasRelatedWork W2348158301 @default.
• W3150870868 hasRelatedWork W2351489958 @default.
• W3150870868 hasRelatedWork W2352070804 @default.
• W3150870868 hasRelatedWork W2355551775 @default.
• W3150870868 hasRelatedWork W2355903501 @default.
• W3150870868 hasRelatedWork W2357382885 @default.
• W3150870868 hasRelatedWork W2368415315 @default.
• W3150870868 hasRelatedWork W2374944354 @default.
• W3150870868 hasRelatedWork W2379773066 @default.
• W3150870868 hasRelatedWork W2391872244 @default.
• W3150870868 hasRelatedWork W2888371417 @default.
• W3150870868 hasRelatedWork W2999394651 @default.
• W3150870868 hasRelatedWork W3000713131 @default.
• W3150870868 hasRelatedWork W3145512305 @default.
• W3150870868 hasRelatedWork W2577110483 @default.

• next