FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150871398> ?p ?o ?g. }

• W3150871398 endingPage "44" @default.
• W3150871398 startingPage "37" @default.
• W3150871398 abstract "The synthesis, antimicrobial, and antioxidant activities of new quinoline analogs were carried out with the aim to find possible hits/leads that can be taken up for future drug development. A series of 2-amino-N’-((2-chloroquinolin-3-yl)methylene)acetohydrazide derivatives (6a-h) have been synthesized by reacting 2-chloro-N’-((2-chloroquinolin-3-yl)methylene)acetohydrazide (5a) and N’-((6-bromo-2-chloroquinolin-3-yl)methylene)-2-chloroacetohydrazide (5b) with secondary amines (Morpholine, diethylamine, piperidine and 1-methylpiperazine). The characterization was achieved by FT-IR, 1H NMR, 13C NMR, and mass spectral analysis. The in silico ADMET studies of the synthesized molecules were analyzed for their drug likeliness and toxic properties. The ADMET study indicates that the synthesized compounds were found to be possessing reliable ADME properties and are nontoxic. The antimicrobial properties were tested against bacterial and fungal species with amoxicillin and fluconazole as standard drugs. The compounds 6a, 6c, 6e, and 6g exhibited good antibacterial potency against P. aeruginosa, and the compounds 6a, 6f, and 6h have shown good activity against E. coli with 1000 µg/mL. The compounds 6b, 6c, and 6e have moderate activity against fungal species C. oxysporum and the compounds 6c, 6e, 6f, 6g, and 6h have good activity against P. chrysogenum. Synthesized compounds were also tested for the DPPH· free radical scavenging activity to check the antioxidant potential, and the results revealed that the compounds 6a, 6b, 6c, and 6e have exhibited antioxidant potency than the remaining synthesized derivatives. The possible hits generated from biological activity could be taken for the generation of lead molecules for the drug discovery of antimicrobial and antioxidant entities from quinoline." @default.
• W3150871398 created "2021-04-13" @default.
• W3150871398 creator A5024191540 @default.
• W3150871398 creator A5057745076 @default.
• W3150871398 creator A5080417870 @default.
• W3150871398 date "2021-03-31" @default.
• W3150871398 modified "2023-10-10" @default.
• W3150871398 title "Synthesis, antimicrobial, antioxidant, and ADMET studies of quinoline derivatives" @default.
• W3150871398 cites W1973856448 @default.
• W3150871398 cites W1978669230 @default.
• W3150871398 cites W1988841455 @default.
• W3150871398 cites W1991221124 @default.
• W3150871398 cites W1993918831 @default.
• W3150871398 cites W1999629046 @default.
• W3150871398 cites W2000470970 @default.
• W3150871398 cites W2004318415 @default.
• W3150871398 cites W2009547038 @default.
• W3150871398 cites W2011244063 @default.
• W3150871398 cites W2014858249 @default.
• W3150871398 cites W2036172744 @default.
• W3150871398 cites W2066140141 @default.
• W3150871398 cites W2076639843 @default.
• W3150871398 cites W2090632754 @default.
• W3150871398 cites W2106776037 @default.
• W3150871398 cites W2130948107 @default.
• W3150871398 cites W2131968411 @default.
• W3150871398 cites W2141493842 @default.
• W3150871398 cites W2148464409 @default.
• W3150871398 cites W2319729310 @default.
• W3150871398 cites W2332871445 @default.
• W3150871398 cites W2333398755 @default.
• W3150871398 cites W2345956255 @default.
• W3150871398 cites W2410476068 @default.
• W3150871398 cites W2461809650 @default.
• W3150871398 cites W2528842739 @default.
• W3150871398 cites W2788039892 @default.
• W3150871398 cites W2790364571 @default.
• W3150871398 cites W2908129609 @default.
• W3150871398 cites W2972885271 @default.
• W3150871398 cites W2993056743 @default.
• W3150871398 cites W3038467715 @default.
• W3150871398 cites W3046045485 @default.
• W3150871398 cites W3081053671 @default.
• W3150871398 doi "https://doi.org/10.5155/eurjchem.12.1.37-44.2038" @default.
• W3150871398 hasPublicationYear "2021" @default.
• W3150871398 type Work @default.
• W3150871398 sameAs 3150871398 @default.
• W3150871398 citedByCount "2" @default.
• W3150871398 countsByYear W31508713982022 @default.
• W3150871398 countsByYear W31508713982023 @default.
• W3150871398 crossrefType "journal-article" @default.
• W3150871398 hasAuthorship W3150871398A5024191540 @default.
• W3150871398 hasAuthorship W3150871398A5057745076 @default.
• W3150871398 hasAuthorship W3150871398A5080417870 @default.
• W3150871398 hasBestOaLocation W31508713981 @default.
• W3150871398 hasConcept C103319777 @default.
• W3150871398 hasConcept C178790620 @default.
• W3150871398 hasConcept C185592680 @default.
• W3150871398 hasConcept C202751555 @default.
• W3150871398 hasConcept C21951064 @default.
• W3150871398 hasConcept C2776309666 @default.
• W3150871398 hasConcept C2777256644 @default.
• W3150871398 hasConcept C2777454769 @default.
• W3150871398 hasConcept C2778004101 @default.
• W3150871398 hasConcept C2781056017 @default.
• W3150871398 hasConcept C2781401929 @default.
• W3150871398 hasConcept C2781462491 @default.
• W3150871398 hasConcept C4937899 @default.
• W3150871398 hasConcept C55493867 @default.
• W3150871398 hasConcept C69366308 @default.
• W3150871398 hasConcept C71240020 @default.
• W3150871398 hasConceptScore W3150871398C103319777 @default.
• W3150871398 hasConceptScore W3150871398C178790620 @default.
• W3150871398 hasConceptScore W3150871398C185592680 @default.
• W3150871398 hasConceptScore W3150871398C202751555 @default.
• W3150871398 hasConceptScore W3150871398C21951064 @default.
• W3150871398 hasConceptScore W3150871398C2776309666 @default.
• W3150871398 hasConceptScore W3150871398C2777256644 @default.
• W3150871398 hasConceptScore W3150871398C2777454769 @default.
• W3150871398 hasConceptScore W3150871398C2778004101 @default.
• W3150871398 hasConceptScore W3150871398C2781056017 @default.
• W3150871398 hasConceptScore W3150871398C2781401929 @default.
• W3150871398 hasConceptScore W3150871398C2781462491 @default.
• W3150871398 hasConceptScore W3150871398C4937899 @default.
• W3150871398 hasConceptScore W3150871398C55493867 @default.
• W3150871398 hasConceptScore W3150871398C69366308 @default.
• W3150871398 hasConceptScore W3150871398C71240020 @default.
• W3150871398 hasIssue "1" @default.
• W3150871398 hasLocation W31508713981 @default.
• W3150871398 hasOpenAccess W3150871398 @default.
• W3150871398 hasPrimaryLocation W31508713981 @default.
• W3150871398 hasRelatedWork W2064262194 @default.
• W3150871398 hasRelatedWork W2345692188 @default.
• W3150871398 hasRelatedWork W2528842739 @default.
• W3150871398 hasRelatedWork W2598424495 @default.
• W3150871398 hasRelatedWork W2605868823 @default.
• W3150871398 hasRelatedWork W2747915922 @default.
• W3150871398 hasRelatedWork W3150871398 @default.

• next