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- W3150873972 abstract "S u m m a r y . We investigated the effects of mechanical on intracellular calcium concentration ([Ca2+]~) of cultured neonatal rat ventricular cells using microfluorometry with fura-2. Myocytes were cultured on laminin-coated silicon rubber and stretched by pulling the rubber with a manipulator. Myocytes were either mildly stretched (to less than 115% of control length), moderately so (to 115%-125% of control length), or extensively (to over 125% of the control length). 'Quick stretches (accomplished within 10s) of moderate to extensive intensities produced a large transient increase of [Ca2+]~ in the early phase of (30s2min), followed by a small but sustained increase during the late phase of (5-10min). The initial transient increase in [Ca2+]~ after the quick stretch was preserved in the presence of gallopamil (10-7M) or ryanodine (10 -5 M), but was absent in Ca2+-free medium or in the presence of gadolinium (10-7M). The late or steady state [Ca>]~ increase was observed in the presence of gadolinium, gallopamil, or ryanodine but was abolished in Ca2+-free medium. A steady-state increase in [Ca2+]i was also evoked by slow stretch in which ceils were slowly pulled to the final length within 12rain. As the presence of external Ca 2+ was indispensable, increased trans-sarcolemmal Ca 2+ influx appears to be involved in both initial and steady-state increases in [Ca2+]i. The initial increase in [Ca2÷]i after the 'quick stretch can be attributed to the activation of gadolinium-sensitive, stretch-activated channels." @default.
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- W3150873972 date "2007-01-01" @default.
- W3150873972 modified "2023-09-27" @default.
- W3150873972 title "Mechanical stretch increases intracellular calcium concentration in cultured ventricular cells from neonatal rats" @default.
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