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- W3150877519 endingPage "106" @default.
- W3150877519 startingPage "94" @default.
- W3150877519 abstract "Abstract In recent years, n‐butanol, a type of alcohol, has been widely used from the chemical industry to the food industry. In this study, toxic effects of n‐butanol's different concentrations (10, 50, 250, 500, 750, 1,000, and 1,250 mg/L) in Zebrafish Danio rerio embryos and larvae were investigated. For this purpose, Zebrafish embryos were exposed to n‐butanol in acute semistatic applications. Teratogenic effects such as cardiac edema, scoliosis, lordosis, head development abnormality, yolk sac edema, and tail abnormality were determined at different time intervals (24, 48, 72, 96, and 120 h). Additionally, histopathological abnormalities such as vacuole formation in brain tissue and necrosis in liver tissue were observed at high doses (500, 750, and 1,000 mg/L) in all treatment groups at 96 h. It was determined that heart rate decreased at 48, 72, and 96 h due to an increase in concentration. In addition, alcohol‐induced eye size reduction (microphthalmia) and single eye formation (cyclopia) are also among the effects observed in our research findings. In conclusion, n‐butanol has been observed to cause intense neurotoxic, teratogenic, and cardiotoxic effects in Zebrafish embryos and larvae." @default.
- W3150877519 created "2021-04-13" @default.
- W3150877519 creator A5018143332 @default.
- W3150877519 creator A5059105075 @default.
- W3150877519 creator A5069639653 @default.
- W3150877519 creator A5083979336 @default.
- W3150877519 creator A5089431764 @default.
- W3150877519 date "2021-03-29" @default.
- W3150877519 modified "2023-10-14" @default.
- W3150877519 title "Teratogenic and Neurotoxic Effects of n‐Butanol on Zebrafish Development" @default.
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