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- W3150894217 abstract "母亲的 Wnt11 为在 Xenopus 胚胎的 Spemann 组织者的形成必要、足够。Xnr3 和 Siamois 在组织者正式就职期间作为母亲的 Wnt11/-catenin 的直接目标基因被识别了。母亲的 XTcf3 的弄空导致了 Xnr3 和 Siamois 的宫外的表示，建议 -catenin/XTcf3 的活动严格地在早 Xenopus 胚胎被调整。这里，我们证明 Xenopus mga (Xmga ) 是为背面的轴形成要求的母亲的基因。Overexpression 实验显示老鼠 Mga 加强在组织者特定的基因的正式就职的 -catenin 的活动。母亲的 Xmga 的弄空导致组织者基因和 ventralization 显型的表示的戏剧的减少，显示 Xmga 为 -catenin 功能和组织者形成被要求。XTcf3 的弄空不能在弄空 Xmga 的胚胎救组织者基因表示和轴形成，建议 Xmga 在组织者正式就职期间的 XTcf3 是下游的。我们断定母亲的 Xmga 在组织者形成和 Xenopus 胚胎的背面的开发期间为 -catenin 的函数是批评的。到我们的知识，这第一次是一份报告含有在调整 Wnt 发信号的 Mga。" @default.
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- W3150894217 date "2012-01-01" @default.
- W3150894217 modified "2023-09-25" @default.
- W3150894217 title "Maternal Mga is required for Wnt signaling and organizer formation in the early Xenopus embryo" @default.
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