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- W3150897639 endingPage "3603" @default.
- W3150897639 startingPage "3603" @default.
- W3150897639 abstract "Host-directed therapy using drugs that target cellular pathways required for virus lifecycle or its clearance might represent an effective approach for treating infectious diseases. Changes in redox homeostasis, including intracellular glutathione (GSH) depletion, are one of the key events that favor virus replication and contribute to the pathogenesis of virus-induced disease. Redox homeostasis has an important role in maintaining an appropriate Th1/Th2 balance, which is necessary to mount an effective immune response against viral infection and to avoid excessive inflammatory responses. It is known that excessive production of reactive oxygen species (ROS) induced by viral infection activates nuclear factor (NF)-kB, which orchestrates the expression of viral and host genes involved in the viral replication and inflammatory response. Moreover, redox-regulated protein disulfide isomerase (PDI) chaperones have an essential role in catalyzing formation of disulfide bonds in viral proteins. This review aims at describing the role of GSH in modulating redox sensitive pathways, in particular that mediated by NF-kB, and PDI activity. The second part of the review discusses the effectiveness of GSH-boosting molecules as broad-spectrum antivirals acting in a multifaceted way that includes the modulation of immune and inflammatory responses." @default.
- W3150897639 created "2021-04-13" @default.
- W3150897639 creator A5023803862 @default.
- W3150897639 creator A5024320794 @default.
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- W3150897639 creator A5051997972 @default.
- W3150897639 creator A5075398108 @default.
- W3150897639 creator A5078368810 @default.
- W3150897639 date "2021-03-30" @default.
- W3150897639 modified "2023-10-18" @default.
- W3150897639 title "Intracellular Redox-Modulated Pathways as Targets for Effective Approaches in the Treatment of Viral Infection" @default.
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