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- W3150903075 endingPage "a040675" @default.
- W3150903075 startingPage "a040675" @default.
- W3150903075 abstract "Genomic information is encoded on long strands of DNA, which are folded into chromatin and stored in a tiny nucleus. Nuclear chromatin is a negatively charged polymer composed of DNA, histones, and various nonhistone proteins. Because of its highly charged nature, chromatin structure varies greatly depending on the surrounding environment (e.g., cations, molecular crowding, etc.). New technologies to capture chromatin in living cells have been developed over the past 10 years. Our view on chromatin organization has drastically shifted from a regular and static one to a more variable and dynamic one. Chromatin forms numerous compact dynamic domains that act as functional units of the genome in higher eukaryotic cells and locally appear liquid-like. By changing DNA accessibility, these domains can govern various functions. Based on new evidences from versatile genomics and advanced imaging studies, we discuss the physical nature of chromatin in the crowded nuclear environment and how it is regulated." @default.
- W3150903075 created "2021-04-13" @default.
- W3150903075 creator A5035675072 @default.
- W3150903075 creator A5038297718 @default.
- W3150903075 creator A5077728722 @default.
- W3150903075 date "2021-04-05" @default.
- W3150903075 modified "2023-10-17" @default.
- W3150903075 title "Physical Nature of Chromatin in the Nucleus" @default.
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