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- W3150903818 abstract "Objectives: To investigate the immune micro-environment in tumors of patients with pancreatic ductal adenocarcinoma (PDAC) after immediate surgery or neoadjuvant therapy and its relation to survival outcome. Methods: We analysed tumor samples from 50 patients without and 53 patients with neoadjuvant chemo-radiotherapy. Immune profiling of FFPE tumor samples was performed using the NanoString PanCancer assay and the expression of 770 immune related genes was measured. We used the two sample T-test for comparison of gene expression levels between the two groups. The multivariate Cox proportional hazards model was performed to identify independent prognostic predictors. The Kaplan-Meier method with a log-rank test was applied to compare the survival distributions between groups. Results: Total tumor infiltrating lymphocytes (TILs) was equally distributed between treatment groups. B cell infiltration was decreased significantly (p< 0,001) in the neoadjuvant group, whereas T cell infiltration did not vary between groups. Furthermore, CXCL12 expression, a chemokine involved in tumor proliferation and progression, was significantly (p< 0,0001) higher in neoadjuvant treated tumors. However, its receptor CXCR4 was down regulated. In addition, high expression of the ALCAM gene was strongly associated with poor prognosis in both treatment arms. Results from immune cell type ratios as prognostic factor will follow. Conclusion: The tumor immune micro-environment after neoadjuvant treatment differs from treatment naïve tumors, indicating that neoadjuvant treatment affects the distribution of immune cells in PDAC tumors." @default.
- W3150903818 created "2021-04-13" @default.
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- W3150903818 date "2021-01-01" @default.
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- W3150903818 title "The Immune Micro-environment of Treatment Naïve and Neoadjuvant Treated Pancreatic Ductal Adenocarcinoma Tissues from the PREOPANC-1 Randomized Controlled Trial" @default.
- W3150903818 doi "https://doi.org/10.1016/j.hpb.2020.11.026" @default.
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