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- W3150929340 abstract "BACKGROUNDAIM: To investigate the acute toxicity and genotoxicity of Marine in mice. MATERIAL AND METHODS: LD 50 test,micronucleus test in peripheral blood PCE and sperm abnormality test were used.The mice were randomly divided into five groups:the negative control(I),the positive control(II),1/2LD 50 (III),1/4LD 50 (IV),1/8LD 50 (V).III,IV,V groups were administrated with different dosages of Marine intraperitoneally. RESULTS: The LD 50 of the Marine was(505±31)mg/kg.Compared to the negative control,the results showed that1/2LD 50 ,1/4LD 50 ,1/8LD 50 groups of24hours micronucleated PCE could significantly increase the micronucleus frequencies in the peripheral blood.The same condition could be observed in1/2LD 50 ,1/4LD 50 ,1/8LD 50 groups of48hours micronucleated PCE.1/2LD 50 group differed from the negative control in the sperm abnormality test,whereas no significant difference has been observed between1/4LD 50 ,1/8LD 50 groups and negative control. CONˉCLUSION: It suggests that the Marine is a low toxicity drug and has genotoxicity to a certain extent." @default.
- W3150929340 created "2021-04-13" @default.
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- W3150929340 date "2004-01-01" @default.
- W3150929340 modified "2023-09-25" @default.
- W3150929340 title "Study on Acute Toxicity of Mice and Micronucleus in Peripheral Blood and Spern Abnormality of Mice Induced by Marine" @default.
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