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- W3150935085 abstract "Objective: To study the effects of HIV Tat protein on CCR5 expression of monocytes and HIV infection in monocytes. Methods: Membrane expression of CCR5 on monocytes was analyzed by flow cytometry.Stimulated with HIV Tat protein,monocytes were infected with monocyte tropic HIV Ba L and HIV gag p24 level in the supernatant was measured by ELISA methods. Results: HIV Tat protein increased CCR5 expression in human monocytes,which was inhibited by rabbit anti Tat polyclonal antibody.Tat protein also increased p24 level after monocyte tropic HIV 1 Ba L infected monocytes. Conclusion: Tat increases CCR5 expression and HIV 1 infection in monocytes,which indicates that HIV Tat might be a key protein in HIV 1 infection. [" @default.
- W3150935085 created "2021-04-13" @default.
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- W3150935085 date "2004-01-01" @default.
- W3150935085 modified "2023-09-25" @default.
- W3150935085 title "Effect of HIV Tat protein on CCR5 expression in monocytes and infection with monocyte tropic HIV strains" @default.
- W3150935085 hasPublicationYear "2004" @default.
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