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- W3150940163 abstract "Ghrelin, 28 氨基酸肽荷尔蒙用胃生产了,是从圆周要发现的第一 orexigenic 荷尔蒙。在 Ser3 的 octanoyl 修正,由 ghrelin O-acyltransferase (山羊) 调停了,为 ghrelins 是必要的生物活动。Ghrelin 在视下丘的弓形的原子核在神经原上通过绑定刺激食物吸入到它的受体(GRLN-R ) 。Ghrelin 广泛地在整个身体被表示;因此,它在几个另外的生理的函数被含有,它包括生长荷尔蒙版本,胃的倒空,并且身体重量规定。Ghrelin 和 GRLN-R 表示也在胰被发现,建议一个本地生理的角色。因此,几最近的研究现在在血葡萄糖动态平衡的规定为 ghrelin 和它的受体向一个重要角色指,它是这评论的主要焦点。由 ghrelin 的这条规定的几机制被建议了,并且一可能性通过胰岛素分泌物的规定。尽管有某争吵,大多数研究建议 ghrelin 在胰岛素分泌物上施加禁止的效果,导致增加的传播葡萄糖层次。Ghrelin 可以因此是一个 diabetogenic 因素。肥胖相关的类型 2 糖尿病成为了一个日益重要的健康问题,在世界上的几乎到达流行比例;因此,表明小径的 ghrelin 山羊的对手,将处理两个精力,和葡萄糖动态平衡,可以为这疾病被认为新治疗同样有希望。" @default.
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- W3150940163 date "2012-01-01" @default.
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- W3150940163 title "Ghrelin's second life: From appetite stimulator to glucose regulator" @default.
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