Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150941646> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W3150941646 abstract "ABSTRACT ToinvestigatetheroleofprimaryTcellrepertoireselectionintheimmunopathogenesisofautoim-munediseases,purethymicepithelium(TE)fromnonobesediabetic(NOD)embryoswasgraftedintononautoimmunepronenewbornC57BL y 6athymicmice.TheresultsshowthatNODTEselectshostTcellrepertoiresthatestablishauto-immunityinotherwisenondiabeticanimals.Thus,suchchi-merasregularlyshowCD4andCD8Tcell-mediatedinsulitisandsialitis,incontrastwithsyngeneicorallogeneicchimerasproducedwithTEfromnonautoimmunestrains.Thisisthefirstdemonstrationthatautoimmunitytopancreatic b cellsandsalivaryglandscanbeestablishedbythesolealterationofthethymicenvironmentinvolvedinTcellselection,regard-lessofthenatureandpresentationofbothmajorhistocom-patibilitycomplexandtissue-specificantigensonthetargetorgan.ThesedataindicatethatTcellrepertoireselectionbytheNODthymicepitheliumissufficienttoinducespecificautoimmunecharacteristicsinthecontextofanotherwisenormalhost. Thenonobesediabetic(NOD)mouseprovidesanexperimen-tal model of human insulin-dependent diabetes mellitus(IDDM).ThesemicespontaneouslydevelopaTcell-mediatedautoimmunedisease,characterizedbyapredominantinflam-mationofpancreaticisletsfollowedbydestructionofbcells,anddiabetes,butaffectingalsootherorganssuchassalivaryglands(1–3)andthyroid(4,5).ThediseaseisprimarilymediatedbyCD4andCD8Tcells(6–14).MultiplegeneticlocicontrolNODmicesusceptibilitytoinsulitisandautoimmuneinflammationinothertissues,butfulldevelopmentofdiabetesrequiresgeneslinkedtomajorhistocompatibilitycomplex(MHC),namelytheexpressionoftheuniqueI-A" @default.
- W3150941646 created "2021-04-13" @default.
- W3150941646 creator A5074487495 @default.
- W3150941646 date "1997-01-01" @default.
- W3150941646 modified "2023-09-27" @default.
- W3150941646 title "Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BLy6 athymic nude mice" @default.
- W3150941646 cites W2133418071 @default.
- W3150941646 hasPublicationYear "1997" @default.
- W3150941646 type Work @default.
- W3150941646 sameAs 3150941646 @default.
- W3150941646 citedByCount "0" @default.
- W3150941646 crossrefType "journal-article" @default.
- W3150941646 hasAuthorship W3150941646A5074487495 @default.
- W3150941646 hasConcept C104317684 @default.
- W3150941646 hasConcept C154945302 @default.
- W3150941646 hasConcept C159654299 @default.
- W3150941646 hasConcept C203014093 @default.
- W3150941646 hasConcept C2776090121 @default.
- W3150941646 hasConcept C2779075594 @default.
- W3150941646 hasConcept C2780130043 @default.
- W3150941646 hasConcept C41008148 @default.
- W3150941646 hasConcept C529295009 @default.
- W3150941646 hasConcept C54355233 @default.
- W3150941646 hasConcept C55851684 @default.
- W3150941646 hasConcept C71924100 @default.
- W3150941646 hasConcept C81917197 @default.
- W3150941646 hasConcept C86803240 @default.
- W3150941646 hasConcept C8891405 @default.
- W3150941646 hasConceptScore W3150941646C104317684 @default.
- W3150941646 hasConceptScore W3150941646C154945302 @default.
- W3150941646 hasConceptScore W3150941646C159654299 @default.
- W3150941646 hasConceptScore W3150941646C203014093 @default.
- W3150941646 hasConceptScore W3150941646C2776090121 @default.
- W3150941646 hasConceptScore W3150941646C2779075594 @default.
- W3150941646 hasConceptScore W3150941646C2780130043 @default.
- W3150941646 hasConceptScore W3150941646C41008148 @default.
- W3150941646 hasConceptScore W3150941646C529295009 @default.
- W3150941646 hasConceptScore W3150941646C54355233 @default.
- W3150941646 hasConceptScore W3150941646C55851684 @default.
- W3150941646 hasConceptScore W3150941646C71924100 @default.
- W3150941646 hasConceptScore W3150941646C81917197 @default.
- W3150941646 hasConceptScore W3150941646C86803240 @default.
- W3150941646 hasConceptScore W3150941646C8891405 @default.
- W3150941646 hasLocation W31509416461 @default.
- W3150941646 hasOpenAccess W3150941646 @default.
- W3150941646 hasPrimaryLocation W31509416461 @default.
- W3150941646 hasRelatedWork W1998700085 @default.
- W3150941646 hasRelatedWork W2011934486 @default.
- W3150941646 hasRelatedWork W2013861152 @default.
- W3150941646 hasRelatedWork W2014964960 @default.
- W3150941646 hasRelatedWork W2022361761 @default.
- W3150941646 hasRelatedWork W2066798646 @default.
- W3150941646 hasRelatedWork W2078001237 @default.
- W3150941646 hasRelatedWork W2109245226 @default.
- W3150941646 hasRelatedWork W2116125353 @default.
- W3150941646 hasRelatedWork W2124870236 @default.
- W3150941646 hasRelatedWork W2133604102 @default.
- W3150941646 hasRelatedWork W2141373423 @default.
- W3150941646 hasRelatedWork W2147286335 @default.
- W3150941646 hasRelatedWork W2152784340 @default.
- W3150941646 hasRelatedWork W2165987960 @default.
- W3150941646 hasRelatedWork W2194791723 @default.
- W3150941646 hasRelatedWork W2211168538 @default.
- W3150941646 hasRelatedWork W2320340716 @default.
- W3150941646 hasRelatedWork W2410457253 @default.
- W3150941646 hasRelatedWork W2958203690 @default.
- W3150941646 isParatext "false" @default.
- W3150941646 isRetracted "false" @default.
- W3150941646 magId "3150941646" @default.
- W3150941646 workType "article" @default.