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- W3150945932 abstract "Objective:To identify the underlying mechanisms of the protective effects of Dingxin Recipe(定心方,DXR),a Chinese compound prescription that has been used clinically in China for more than 20 years, on ischemia/reperfusion(l/R)-induced arrhythmias in rat model.Methods:A total of 30 rats were randomly divided into three groups:sham group,l/R group,and DXR-pretreated l/R(DXR-I/R) group.Rats in the DXR-l /R group were intragastrically administrated with DXR(12.5 g/kg per day) for consecutive 7 days,while rats in the sham and l/R groups were administrated with normal saline.Arrhythmias were introduced by l/R and electrocardiograms(ECG) were recorded.Two-dimensional(2-D) polyacrylamide gel electrophoresis and matrixassisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF MS) were used to identify differentially expressed proteins.Immunohistochemistry,real-time quantitative polymerase chain reaction(RQPCR), Western blot,and enzyme-linked immunosorbent assay(ELISA) were performed to analyze proteins obtained in the above experiments.Results:DXR significantly reduced the incidence and mean duration of ventricular tachycardia and ventricular fibrillation and dramatically decreased the mortality,as well as arrhythmia score,compared with those of the l/R group.Among successfully identified proteins,prohibitin(PHB) and heart fatty acid binding protein(hFABP) were up-regulated in DXR-pretreated l/R rats compared with those of the l/R rats.In addition,compared with the l/R group,the level of glutathione(GSH) was elevated accompanied by reduced expressions of interleukin-6(IL-6) and neutrophil infiltration in l/R rats with DXR pretreatment. Conclusions:DXR could alleviate l/R-induced arrhythmias,which might be related to increased expression of PHB.The enhanced expression of PHB prevented against the depletion of GSH and consequently inhibited apoptosis of cardiomyocytes.Furthermore,up-regulation of PHB might ameliorate l/R-induced cell death and leakage of hFABP by suppressing neutrophil infiltration and IL-6 expressions." @default.
- W3150945932 created "2021-04-13" @default.
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- W3150945932 date "2012-01-01" @default.
- W3150945932 modified "2023-09-23" @default.
- W3150945932 title "Dingxin Recipe(定心方) Prevents Ischemia/Reperfusion-Induced Arrhythmias via Up-regulating Prohibitin and Suppressing Inflammatory Responses" @default.
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