Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150968077> ?p ?o ?g. }
- W3150968077 endingPage "856" @default.
- W3150968077 startingPage "847" @default.
- W3150968077 abstract "Limited knowledge exists on the virulence factors of Candida tropicalis and the mechanisms of azole resistance that lead to an intensified pathogenicity and treatment failure. We aimed to evaluate the virulence factors and molecular mechanisms of azole resistance among C. tropicalis isolated from patients with candidemia. Several virulence factors, including extracellular enzymatic activities, cell surface hydrophobicity (CSH), and biofilm formation, were evaluated. Antifungal susceptibility pattern and expression level of ERG11, UPC2, MDR1, and CDR1 genes of eight (4 fluconazole resistance and 4 fluconazole susceptible) clinical C. tropicalis isolates were assessed. The correlation between the virulence factors and antifungal susceptibility patterns was analyzed. During a 4 year study, forty-five C. tropicalis isolates were recovered from candidemia patients. The isolates expressed different frequencies of virulence determinants as follows: coagulase 4 (8.9%), phospholipase 5 (11.1%), proteinase 31 (68.9%), esterase 43 (95.6%), hemolysin 44 (97.8%), biofilm formation 45 (100%) and CSH 45(100%). All the isolates were susceptible to amphotericin B and showed the highest resistance to voriconazole. There was a significant positive correlation between micafungin minimum inhibitory concentrations (MICs) and hemolysin production (rs = 0.316). However, we found a negative correlation between fluconazole MICs and esterase production (rs = −0.383). We observed the high expression of ERG11 and UPC2 genes in fluconazole-resistant C. tropicalis isolates. C. tropicalis isolated from candidemia patients extensively displayed capacities for biofilm formation, hemolysis, esterase activity, and hydrophobicity. In addition, the overexpression of ERG11 and UPC2 genes was considered one of the possible mechanisms of azole resistance." @default.
- W3150968077 created "2021-04-13" @default.
- W3150968077 creator A5024890025 @default.
- W3150968077 creator A5025607981 @default.
- W3150968077 creator A5031951813 @default.
- W3150968077 creator A5032169594 @default.
- W3150968077 creator A5067890178 @default.
- W3150968077 creator A5089436674 @default.
- W3150968077 date "2021-08-19" @default.
- W3150968077 modified "2023-10-01" @default.
- W3150968077 title "Virulence Factors and Azole-Resistant Mechanism of Candida Tropicalis Isolated from Candidemia" @default.
- W3150968077 cites W1576221764 @default.
- W3150968077 cites W1597653464 @default.
- W3150968077 cites W1893369945 @default.
- W3150968077 cites W1905352638 @default.
- W3150968077 cites W1940720973 @default.
- W3150968077 cites W1950435809 @default.
- W3150968077 cites W1976891952 @default.
- W3150968077 cites W1990717970 @default.
- W3150968077 cites W2003829155 @default.
- W3150968077 cites W2028042667 @default.
- W3150968077 cites W2049669623 @default.
- W3150968077 cites W2051853225 @default.
- W3150968077 cites W2074781711 @default.
- W3150968077 cites W2075411295 @default.
- W3150968077 cites W2090282785 @default.
- W3150968077 cites W2096278477 @default.
- W3150968077 cites W2102213722 @default.
- W3150968077 cites W2105761493 @default.
- W3150968077 cites W2108388947 @default.
- W3150968077 cites W2148454645 @default.
- W3150968077 cites W2148847026 @default.
- W3150968077 cites W2150921776 @default.
- W3150968077 cites W2153336090 @default.
- W3150968077 cites W2156260604 @default.
- W3150968077 cites W2159475709 @default.
- W3150968077 cites W2160897556 @default.
- W3150968077 cites W2279117823 @default.
- W3150968077 cites W2337862117 @default.
- W3150968077 cites W2468281748 @default.
- W3150968077 cites W2511677978 @default.
- W3150968077 cites W2575270489 @default.
- W3150968077 cites W2596725497 @default.
- W3150968077 cites W2602369823 @default.
- W3150968077 cites W2750774839 @default.
- W3150968077 cites W2758349052 @default.
- W3150968077 cites W2764236009 @default.
- W3150968077 cites W2901497815 @default.
- W3150968077 cites W2905320345 @default.
- W3150968077 cites W2913082887 @default.
- W3150968077 cites W2942787072 @default.
- W3150968077 cites W2966115731 @default.
- W3150968077 cites W2994629262 @default.
- W3150968077 cites W3003739304 @default.
- W3150968077 cites W3021597993 @default.
- W3150968077 cites W3154142018 @default.
- W3150968077 doi "https://doi.org/10.1007/s11046-021-00580-y" @default.
- W3150968077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34410566" @default.
- W3150968077 hasPublicationYear "2021" @default.
- W3150968077 type Work @default.
- W3150968077 sameAs 3150968077 @default.
- W3150968077 citedByCount "7" @default.
- W3150968077 countsByYear W31509680772022 @default.
- W3150968077 countsByYear W31509680772023 @default.
- W3150968077 crossrefType "journal-article" @default.
- W3150968077 hasAuthorship W3150968077A5024890025 @default.
- W3150968077 hasAuthorship W3150968077A5025607981 @default.
- W3150968077 hasAuthorship W3150968077A5031951813 @default.
- W3150968077 hasAuthorship W3150968077A5032169594 @default.
- W3150968077 hasAuthorship W3150968077A5067890178 @default.
- W3150968077 hasAuthorship W3150968077A5089436674 @default.
- W3150968077 hasBestOaLocation W31509680772 @default.
- W3150968077 hasConcept C104317684 @default.
- W3150968077 hasConcept C104810894 @default.
- W3150968077 hasConcept C136139683 @default.
- W3150968077 hasConcept C181199279 @default.
- W3150968077 hasConcept C2775835631 @default.
- W3150968077 hasConcept C2779548794 @default.
- W3150968077 hasConcept C2780315139 @default.
- W3150968077 hasConcept C2780651595 @default.
- W3150968077 hasConcept C2780690907 @default.
- W3150968077 hasConcept C2780917455 @default.
- W3150968077 hasConcept C523546767 @default.
- W3150968077 hasConcept C54355233 @default.
- W3150968077 hasConcept C55493867 @default.
- W3150968077 hasConcept C58123911 @default.
- W3150968077 hasConcept C60987743 @default.
- W3150968077 hasConcept C86803240 @default.
- W3150968077 hasConcept C89423630 @default.
- W3150968077 hasConceptScore W3150968077C104317684 @default.
- W3150968077 hasConceptScore W3150968077C104810894 @default.
- W3150968077 hasConceptScore W3150968077C136139683 @default.
- W3150968077 hasConceptScore W3150968077C181199279 @default.
- W3150968077 hasConceptScore W3150968077C2775835631 @default.
- W3150968077 hasConceptScore W3150968077C2779548794 @default.
- W3150968077 hasConceptScore W3150968077C2780315139 @default.
- W3150968077 hasConceptScore W3150968077C2780651595 @default.
- W3150968077 hasConceptScore W3150968077C2780690907 @default.