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- W3150971461 abstract "Aim: The purpose of this study is to search the effects and treatment efficacies of topotecan and folic
 acid on the choriocarcinoma cultures generated in JAR cell culture.
 Material and Methods: Human choriocarcinoma-like JAR cell is augmented in the 10% fetal bovis
 serum and RPMI-1640 media, 95% air at 37°C with the existence of penicillin and streptomycin. Groups
 to apply topotecan or folic acid are identified as below:Topotecan dissolved in dimethyl sulphoxide
 (DMSO) and prepared as separate doses of 1, 5, 10 and 50 μg/ml. Substances are given to cells
 simultaneously.
 Results: In this study, the apoptotic effect of the use of topotecan only, in residual doses on JAR cell
 series is statistically significant. The use of folic acid only, in residual doses has found to decrease the
 apoptosis. In the combination of these two drugs in residual doses, the apoptotic effect of this drug is
 even more increased, and statistically significant.
 Conclusion: This is the first study which use the topotecan and folic acid separately and combined on
 JAR, a human choriocarcinoma cell line model, and evaluation of β-hCG and h-hCG by the means of
 immunoenzymatic method on the both two cell lines. Synergistic and apoptotic data gathered indicates
 that topotecan and folic acid can be one of the treatment options in order to struggle multi-drug resistance
 which is an enormous obstacle on treatment. However, the efficacy of drugs and effects of combination
 therapies might be disparate in vivo; therefore data must be supported by animal experiments and after
 that by clinical evaluations." @default.
- W3150971461 created "2021-04-13" @default.
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- W3150971461 date "2021-04-03" @default.
- W3150971461 modified "2023-10-14" @default.
- W3150971461 title "Investigation of Topotecan and Folic Acid Effect in Jar Choriocarcinoma Cell Culture" @default.
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- W3150971461 doi "https://doi.org/10.29058/mjwbs.784945" @default.
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