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- W3151035265 abstract "瞄准：在裸体鼠标，和在 Bcl-2 和 Bax 的这 apoptosis 和表达式之间的关系调查 SG7901 房间的植入的肿瘤的导致 genistein 的 apoptosis。方法：由把人的 SG7901 房间注入裸体老鼠的皮下组织建立一个移植肿瘤模特儿。Genistein (0.5， 1 和 1.5 mg/kg ) 直接被注射邻近肿瘤，在 2-d 间隔的六次。然后，在肿瘤体积的变化连续地被测量，每个组的肿瘤抑制率是计算的。我们由传播电子显微镜学(TEM ) 观察了词法改变，由染色方法的 TUNEL 测量了 apoptotic 率，并且检测了由免疫的调整 apoptosis 的基因 Bcl-2 和 bax 的表示组织化学的染色和 RT-PCR。结果：Genistein 0.5，当它被 10.8% ， 29.9% 和 39.6% 分别地在肿瘤附近注射时， 1 和 1.5 mg/kg 显著地禁止了癌生长。Genistein 导致了植入的肿瘤房间经历 apoptosis，与 TEM 看见的 apoptotic 特征。apoptosis 索引与增加 genistein 剂量日益增多地被增加(28.9%+/-1.2% ， 33.8%+/-1.6% 和 37.7%+/-1.2%) 。 Bcl-2 蛋白质的积极的率日益增多地被减少(11.9%+/-0.9%，5.9%+/-0.7%和4.2%+/-0.6%)，并且 bax 蛋白质的积极的率日益增多地被增加(0.9%+/-1.7%，24.9%+/-0.8%和29.6%+/-1.7%)由免疫组织化学的染色，与增加 genistein 的剂量。Bcl-2 mRNA 的密度日益增多地减少了， bax mRNA 的密度由 RT-PCR 与时间的延伸日益增多地增加了。结论：Genistein 能导致移植肿瘤房间的 apoptosis。这 apoptosis 可以被调整 apoptosis 的基因 Bcl-2 的下面规定和调整 apoptosis 的基因 bax 的起来规定调停。" @default.
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- W3151035265 date "2008-01-01" @default.
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- W3151035265 title "Anticancer activity of genistein on implanted tumor of human SG7901 cells in nude mice" @default.
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