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- W3151036313 abstract "Object. The extracellular Mg++ has a vasodilatory effect on the cerebral artery. The present study investigated the effect of intracisternal injection of MgSO4 solution on cerebral vasospasm in a canine model of subarachnoid hemorrhage (SAH). Methods. Subarachnoid hemorrhage was induced in 10 beagles using the twohemorrhage model. Angiography of the vertebrobasilar artery was performed on Day 1 (baseline values before SAH) and on Day 7 (during cerebral vasospasm after induced SAH) before and after intracisternal injection of 0.5 ml/kg of 15 mmol/L MgSO4 solution into the cerebellomedullary cistern. Results. The cerebrospinal fluid Mg ++ concentration was significantly increased to 3.15 ± 1.14 mEq/L after intra cisternal injection from the preinjection value (1.45 ± 0.09 mEq/L; p < 0.01). The diameters of the basilar artery, ver tebral artery, and superior cerebellar artery on Day 7 were significantly decreased to 58.0 ± 10.9%, 71.0 ± 10.1%, and 60.9 ± 13.8%, respectively, of their baseline diameters on Day 1 (p < 0.01). After intracisternal injection of MgSO4, these diameters significantly increased to 73.8 ± 14.3%, 83.0 ± 14.8%, and 74.1 ± 13.5%, respectively (p < 0.01). Conclusions. Intracisternal injection of MgSO4 solution causes significant dilation of spastic cerebral arteries in the canine twohemorrhage model of SAH. (DOI: 10.3171/2008.4.17494) Key W or D s • cerebrospinal fluid • magnesium sulfate • subarachnoid hemorrhage • vasospasm" @default.
- W3151036313 created "2021-04-13" @default.
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- W3151036313 date "2009-01-01" @default.
- W3151036313 modified "2023-09-24" @default.
- W3151036313 title "Novel vasodilatory effect of intracisternal injection of magnesium sulfate solution on spastic cerebral arteries in the canine twohemorrhage model of subarachnoid hemorrhage" @default.
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