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- W3151243225 abstract "CD59 可以由绑定禁止补充的 cytolytic 活动到 C8/C9 并且保护主人房间膜免于相应的膜攻击建筑群(MAC ) 。然而， CD59 是广泛地肿瘤房间上的 overexpressed，它在 tumorigenesis 被含有。相对 MAC 的 CD59 的活跃地点仍然被糊涂。是报导 MAC 有约束力的地点在蛋白质的远侧的脸在残余 W40 附近集中了的膜上位于一条恐水病的沟的附近。这里，二指导地点的 mutagenesis 被重叠延期 PCR 执行删除残余 W40 地点(异种 1， M1 ) 或把 C39W40K41 改变到 W39W40W41 (异种 2， M2 ) 。然后，我们构造了变异的 CD59 真核细胞的表达式系统并且与野类型的 CD59 相比在 CHO 房间上调查了他们的生物函数。表示 recombinant 蛋白质的 CHO 房间的稳定的人口被 immunotechnique 屏蔽。在 30 段落 culturing 以后，蛋白质能被测试。染料版本试金建议 M1CD59 对补充失去这项活动，当 M2CD59 稍微增加反补充活动时。结果显示人的 CD59 的 W40 对它的活动重要，并且这个地点的禁止可以是增加补充活动并且治疗肿瘤的一个潜在的方法。" @default.
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- W3151243225 date "2008-01-01" @default.
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- W3151243225 title "Activity after Site-Directed Mutagenesis of CD59 on Complement-Mediated Cytolysis" @default.
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