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- W3151250693 abstract "Shp2 ，由 PTPN11 基因编码了为人，是包含二N终端 Src 相同的无所不在地表示的蛋白质酷氨酸磷酸酶 2 ( SH2 )领域( N-SH2 ， C-SH2 ，分别地)，一个催化蛋白质酷氨酸磷酸酶( PTP )领域，并且C终端与 tyrosyl 磷酸化地点和一个prolyl富有的主题跟踪。我们 Shp2 的生物函数的理解的进步清楚地证明了 Shp2 不仅在正常造血的房间和另外的哺乳动物的房间的生物学，而且在白血病和另外的肿瘤的开发起一个重要作用。最最近，当第一 proto-oncogenethat 编码蛋白质酷氨酸磷酸酶， PTPN11 基因坚定地被建立了。在造血的系统，最如果 Shp2 的并非所有功能是充当一个积极部件，那为通过表明包含英皇家空军之阶级最低之兵， Akt 和 STAT5 的小径的规定的造血的房间的增长或幸存是必要的。" @default.
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- W3151250693 date "2007-01-01" @default.
- W3151250693 modified "2023-09-23" @default.
- W3151250693 title "Shp2, a novel oncogenic tyrosine phosphatase and potential therapeutic target for human leukemia" @default.
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