Matches in SemOpenAlex for { <https://semopenalex.org/work/W3151251330> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3151251330 abstract "Acute kidney injury (AKI) is an extremely common medical affliction resulting from hypoxic, nephrotoxic and septic insults affecting approximately 20% of all hospital patients and up to 50% of patients in the intensive care unit. There are currently no therapeutics for patients that suffer AKI. Much recent work has focused on designing and implementing therapeutics for AKI. The sirtuins are a family of enzymes that play critical roles in regulating many cellular and biological functions. There are 7 mammalian sirtuins (Sirt1-7) that are known to regulate the acylation of a wide variety of pathways. Furthermore, all but one of the mammalian sirtuins have been shown to be important in mediating AKI based on preclinical studies. These diverse enzymes show exciting potential for therapeutic manipulation. While considerable research has been done on SIRT1 and its role in the kidney, much less is known about mitochondrial SIRT5 in the context of AKI. My research has strove to elucidate the role of SIRT5 in acute kidney injury through in vivo mouse studies and in vitro means with a particular focus on its function as a regulator of fatty acid oxidation." @default.
- W3151251330 created "2021-04-13" @default.
- W3151251330 creator A5020642105 @default.
- W3151251330 date "2020-09-29" @default.
- W3151251330 modified "2023-09-27" @default.
- W3151251330 title "Sirtuins in Kidney Injury and Disease" @default.
- W3151251330 hasPublicationYear "2020" @default.
- W3151251330 type Work @default.
- W3151251330 sameAs 3151251330 @default.
- W3151251330 citedByCount "0" @default.
- W3151251330 crossrefType "journal-article" @default.
- W3151251330 hasAuthorship W3151251330A5020642105 @default.
- W3151251330 hasConcept C104317684 @default.
- W3151251330 hasConcept C126189478 @default.
- W3151251330 hasConcept C126322002 @default.
- W3151251330 hasConcept C151730666 @default.
- W3151251330 hasConcept C177713679 @default.
- W3151251330 hasConcept C203014093 @default.
- W3151251330 hasConcept C2777628635 @default.
- W3151251330 hasConcept C2778384902 @default.
- W3151251330 hasConcept C2779343474 @default.
- W3151251330 hasConcept C2780091579 @default.
- W3151251330 hasConcept C2780472472 @default.
- W3151251330 hasConcept C55493867 @default.
- W3151251330 hasConcept C60644358 @default.
- W3151251330 hasConcept C6929976 @default.
- W3151251330 hasConcept C71924100 @default.
- W3151251330 hasConcept C86803240 @default.
- W3151251330 hasConcept C98274493 @default.
- W3151251330 hasConceptScore W3151251330C104317684 @default.
- W3151251330 hasConceptScore W3151251330C126189478 @default.
- W3151251330 hasConceptScore W3151251330C126322002 @default.
- W3151251330 hasConceptScore W3151251330C151730666 @default.
- W3151251330 hasConceptScore W3151251330C177713679 @default.
- W3151251330 hasConceptScore W3151251330C203014093 @default.
- W3151251330 hasConceptScore W3151251330C2777628635 @default.
- W3151251330 hasConceptScore W3151251330C2778384902 @default.
- W3151251330 hasConceptScore W3151251330C2779343474 @default.
- W3151251330 hasConceptScore W3151251330C2780091579 @default.
- W3151251330 hasConceptScore W3151251330C2780472472 @default.
- W3151251330 hasConceptScore W3151251330C55493867 @default.
- W3151251330 hasConceptScore W3151251330C60644358 @default.
- W3151251330 hasConceptScore W3151251330C6929976 @default.
- W3151251330 hasConceptScore W3151251330C71924100 @default.
- W3151251330 hasConceptScore W3151251330C86803240 @default.
- W3151251330 hasConceptScore W3151251330C98274493 @default.
- W3151251330 hasLocation W31512513301 @default.
- W3151251330 hasOpenAccess W3151251330 @default.
- W3151251330 hasPrimaryLocation W31512513301 @default.
- W3151251330 hasRelatedWork W1981070369 @default.
- W3151251330 hasRelatedWork W2055539528 @default.
- W3151251330 hasRelatedWork W2135819728 @default.
- W3151251330 hasRelatedWork W2510862199 @default.
- W3151251330 hasRelatedWork W2743743758 @default.
- W3151251330 hasRelatedWork W2787244173 @default.
- W3151251330 hasRelatedWork W2810040104 @default.
- W3151251330 hasRelatedWork W2887317314 @default.
- W3151251330 hasRelatedWork W2892474189 @default.
- W3151251330 hasRelatedWork W2908928410 @default.
- W3151251330 hasRelatedWork W3011659105 @default.
- W3151251330 hasRelatedWork W3025621609 @default.
- W3151251330 hasRelatedWork W3032904360 @default.
- W3151251330 hasRelatedWork W3048232588 @default.
- W3151251330 hasRelatedWork W3085820606 @default.
- W3151251330 hasRelatedWork W3119393945 @default.
- W3151251330 hasRelatedWork W3125611445 @default.
- W3151251330 hasRelatedWork W3133554977 @default.
- W3151251330 hasRelatedWork W3135038744 @default.
- W3151251330 hasRelatedWork W3173363561 @default.
- W3151251330 isParatext "false" @default.
- W3151251330 isRetracted "false" @default.
- W3151251330 magId "3151251330" @default.
- W3151251330 workType "article" @default.