Matches in SemOpenAlex for { <https://semopenalex.org/work/W3151266872> ?p ?o ?g. }
- W3151266872 abstract "Abstract Cellular senescence is an irreversible growth arrest that occurs as a result of damaging stimuli, including DNA damage and/or telomere shortening. Here, we investigate histone variant H2A.J as a new biomarker to detect senescent cells during human skin aging. Skin biopsies from healthy volunteers of different ages (18–90 years) were analyzed for H2A.J expression and other parameters involved in triggering and/or maintaining cellular senescence. In the epidermis, the proportions of H2A.J-expressing keratinocytes increased from ≈20% in young to ≈60% in aged skin. Inverse correlations between Ki67- and H2A.J staining in germinative layers may reflect that H2A.J-expressing cells having lost their capacity to divide. As cellular senescence is triggered by DNA-damage signals, persistent 53BP1-foci, telomere lengths, and telomere-associated damage foci were analyzed in epidermal keratinocytes. Only slight age-related telomere attrition and few persistent nuclear 53BP1-foci, occasionally colocalizing with telomeres, suggest that unprotected telomeres are not a significant cause of senescence during skin aging. Quantification of integrin-α6+ basal cells suggests that the number and function of stem/progenitor cells decreased during aging and their altered proliferation capacities resulted in diminished tissue renewal with epidermal thinning. Collectively, our findings suggest that H2A.J is a sensitive marker of epidermal aging in human skin." @default.
- W3151266872 created "2021-04-13" @default.
- W3151266872 creator A5006852883 @default.
- W3151266872 creator A5013510344 @default.
- W3151266872 creator A5017713861 @default.
- W3151266872 creator A5051785622 @default.
- W3151266872 creator A5055681542 @default.
- W3151266872 creator A5056249211 @default.
- W3151266872 creator A5065438956 @default.
- W3151266872 creator A5082038985 @default.
- W3151266872 date "2021-04-01" @default.
- W3151266872 modified "2023-10-18" @default.
- W3151266872 title "Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis" @default.
- W3151266872 cites W1524549603 @default.
- W3151266872 cites W1659141691 @default.
- W3151266872 cites W1966755977 @default.
- W3151266872 cites W1967033366 @default.
- W3151266872 cites W1967229192 @default.
- W3151266872 cites W1968867124 @default.
- W3151266872 cites W1970108285 @default.
- W3151266872 cites W1972655555 @default.
- W3151266872 cites W1973697421 @default.
- W3151266872 cites W1978720331 @default.
- W3151266872 cites W1981689275 @default.
- W3151266872 cites W1982098423 @default.
- W3151266872 cites W1982481909 @default.
- W3151266872 cites W1983673827 @default.
- W3151266872 cites W1986988817 @default.
- W3151266872 cites W1988910648 @default.
- W3151266872 cites W1994873752 @default.
- W3151266872 cites W1997006958 @default.
- W3151266872 cites W1999718358 @default.
- W3151266872 cites W2000441909 @default.
- W3151266872 cites W2030795773 @default.
- W3151266872 cites W2036639619 @default.
- W3151266872 cites W2036982862 @default.
- W3151266872 cites W2065379807 @default.
- W3151266872 cites W2075158658 @default.
- W3151266872 cites W2088566849 @default.
- W3151266872 cites W2092476887 @default.
- W3151266872 cites W2094346386 @default.
- W3151266872 cites W2096587251 @default.
- W3151266872 cites W2108887402 @default.
- W3151266872 cites W2126525177 @default.
- W3151266872 cites W2129298171 @default.
- W3151266872 cites W2130458932 @default.
- W3151266872 cites W2132012237 @default.
- W3151266872 cites W2151850423 @default.
- W3151266872 cites W2154272251 @default.
- W3151266872 cites W2157157405 @default.
- W3151266872 cites W2290981040 @default.
- W3151266872 cites W2299859137 @default.
- W3151266872 cites W2408333379 @default.
- W3151266872 cites W2468408838 @default.
- W3151266872 cites W2559776465 @default.
- W3151266872 cites W2601099946 @default.
- W3151266872 cites W2607214955 @default.
- W3151266872 cites W2613773167 @default.
- W3151266872 cites W2733273049 @default.
- W3151266872 cites W2767673366 @default.
- W3151266872 cites W2780842567 @default.
- W3151266872 cites W2797583006 @default.
- W3151266872 cites W2810861436 @default.
- W3151266872 cites W2892224724 @default.
- W3151266872 cites W2980879216 @default.
- W3151266872 cites W3095651720 @default.
- W3151266872 cites W3109678103 @default.
- W3151266872 doi "https://doi.org/10.1038/s41514-021-00060-z" @default.
- W3151266872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8016850" @default.
- W3151266872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33795696" @default.
- W3151266872 hasPublicationYear "2021" @default.
- W3151266872 type Work @default.
- W3151266872 sameAs 3151266872 @default.
- W3151266872 citedByCount "25" @default.
- W3151266872 countsByYear W31512668722021 @default.
- W3151266872 countsByYear W31512668722022 @default.
- W3151266872 countsByYear W31512668722023 @default.
- W3151266872 crossrefType "journal-article" @default.
- W3151266872 hasAuthorship W3151266872A5006852883 @default.
- W3151266872 hasAuthorship W3151266872A5013510344 @default.
- W3151266872 hasAuthorship W3151266872A5017713861 @default.
- W3151266872 hasAuthorship W3151266872A5051785622 @default.
- W3151266872 hasAuthorship W3151266872A5055681542 @default.
- W3151266872 hasAuthorship W3151266872A5056249211 @default.
- W3151266872 hasAuthorship W3151266872A5065438956 @default.
- W3151266872 hasAuthorship W3151266872A5082038985 @default.
- W3151266872 hasBestOaLocation W31512668721 @default.
- W3151266872 hasConcept C104317684 @default.
- W3151266872 hasConcept C105702510 @default.
- W3151266872 hasConcept C143425029 @default.
- W3151266872 hasConcept C16005928 @default.
- W3151266872 hasConcept C177336024 @default.
- W3151266872 hasConcept C2776458125 @default.
- W3151266872 hasConcept C2777459323 @default.
- W3151266872 hasConcept C2909910311 @default.
- W3151266872 hasConcept C522857546 @default.
- W3151266872 hasConcept C54355233 @default.
- W3151266872 hasConcept C552990157 @default.
- W3151266872 hasConcept C64927066 @default.
- W3151266872 hasConcept C71924100 @default.