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- W3151293504 abstract "Objective To study the effects of nickel-refining dusts on DNA damage in mouse NIH/3T3 cell. Method DNA damage of mouse NIH/3T3 cell induced by two nickel-refining dust samples was determined with single cell gel electrophoresis(SCGE) technique. Results (1)Under the condition of the same treatment time,the tailed cell(%) of NIH/3T3 cells increased with the increase in doses of nickel-refining dusts(35.5%,69.7%,85.2%,41.3%,75.7%,89.2% respectively except for sample 2,50 μg/ml,24 h group),and DNA strand breaks reached the peak value at 4 h of exposure;(2)When we treated the NIH/3T3 cells with the same dose of nickel-refining dusts,the tail rate at 4 h was higher than those at 2 h and 24 h of exposure;(3)Both sample 1 and sample 2 with different doses of nickel-refining dusts could induce higher comet tail,DNA%,tail length(except for 12.5 μg/ml),extent of TM(except for sample 1,12.5 μg/ml) than in control group(P0.05).The DNA damage range was significantly increased in different tested doses of nickel-refining dusts and the damage range reached the peak value when the cells were treated for 4 h. Conclusion Nickel-refining dusts could induce different degree DNA damage in NIH/3T3 cells." @default.
- W3151293504 created "2021-04-13" @default.
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- W3151293504 date "2005-01-01" @default.
- W3151293504 modified "2023-09-25" @default.
- W3151293504 title "Experimental study on the DNA damage of NIH/3T3 cells induced by nickel-refining dusts" @default.
- W3151293504 hasPublicationYear "2005" @default.
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