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- W3151362015 abstract "Objective To investigate the correlation between insulin resistance(IR) and coronary artery disease in patients with normal glucose tolerance.Methods One hundred and twenty-nine patients with normal glucose tolerance,who visited Zhejiang Hospital from January 2007 to December 2010,were enrolled in the present study and were divided into two groups according to homeostatic model assessment(HOMA) of insulin sensitivity index(ISI): insulin sensitive group(IS,n=68) and IR group(n=61).The total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),homocysteine(HCY),and uric acid(UA) were measured for each patient using an auto biochemistry analyzer.Selective coronary angiography and Gensini score were performed on all the patients.Spearman's correlations and stepwise multiple regression analysis were used in the data analysis.Results The coronary artery lesions were more severe in the IR group than in the IS group.The percentages of normal and one-vessel disease were significantly lower in the IR group(both 11.8%) than in the IS group(29.8% and 26.3%,respectively,P0.05).The percentage of multi-vessel disease and Gensini score were significantly higher in the IR group(49.0% and 32.2±34.3,respectively) than in the IS group(14.1% and 10.6±12.7,respectively,P0.01).A negative correlation was identified through partial correlation analysis between the Gensini score and ISI(r=-0.354,P0.01) after adjusting for influential factors.Stepwise multiple linear regression analysis indicated that ISI and HCY are the independent factors for the Gensini score.Conclusion Insulin resistance is closely correlated with the severity of coronary artery lesions,and is an independent risk factor for coronary artery disease in patients with normal glucose tolerance." @default.
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- W3151362015 date "2011-01-01" @default.
- W3151362015 modified "2023-09-23" @default.
- W3151362015 title "Correlation between insulin resistance and coronary artery disease in patients with normal glucose tolerance" @default.
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