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• W3151365718 abstract "ABSTRACT Classic cell lineage studies in the nematode Caenorhabditis elegans as well as recent lineage tracing in vertebrates have shown that cells of the same type can be generated by distinct cellular lineages that originate in different parts of the developing embryo (“lineage convergence”). Several C. elegans neuron classes composed of left/right or radially symmetric class members display such lineage convergence, in that individual neurons of the same class derive from distinct, non-bilaterally symmetric lineages. We show here that the C. elegans Atonal homolog lin-32/Ato , a bHLH transcription factor, is differentially expressed in neuronal lineages that give rise to left/right or radially symmetric class members. Loss of lin-32/Ato results in the selective loss of the expression of panneuronal markers and terminal selector-type transcription factors that confer neuron class-specific features. We discovered that another bHLH transcription factor, the Achaete Scute-homolog hlh-14 is expressed in mirror image pattern to lin-32/Ato in a subset of the left/right symmetric neuron pairs and is required to induce neuronal identity and terminal selector expression on the contralateral side of the animal. These findings demonstrate that distinct lineage histories converge via distinct bHLH factors on the level of induction of terminal selector identity determinants, which thus serve as integrators of distinct lineage histories. We also describe neuron-to-neuron identity transformations in lin-32/Ato mutants, which we propose to also be the result of misregulation of terminal selector gene expression." @default.
• W3151365718 created "2021-04-13" @default.
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• W3151365718 date "2021-03-31" @default.
• W3151365718 modified "2023-09-23" @default.
• W3151365718 title "Piecemeal regulation of convergent neuronal lineages by bHLH transcription factors in<i>C. elegans</i>" @default.
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• W3151365718 doi "https://doi.org/10.1101/2021.03.31.437939" @default.
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