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- W3151394278 abstract "hPFTAIRE1 is a Cdc2-related kinase family member.To search its substrates and regulatory proteins,hPFTAIRE1 was fused to LexA and used as a bait to screen a human brain LexA two-hybrid library. In this screening,seven hPFTAIRE1 interacting proteins,including promyelocytic leukemia zinc finger (PLZF), were obtained.The interaction between PLZF and hPFTAIRE1 was confirmed by β-galactosidase assay and Leu growth activity.PLZF encodes a transcription factor belonging to the POZ/BTB domain and Kruppel zinc finger (POK) family.The highly conserved POZ/BTB domain plays a critical role in protein-protein interaction.We deleted the POZ/BTB and Kruppel zinc finger domains,respectively,and observed the inter- action between hPFTAIRE1 and truncated PLZFs by liquid β-galactosidase activity assay.A weak interaction was detected between hPFTAIRE1 and PLZF.We also observed the interaction between PLZF and another Cdc2-related kinase,PCTAIRE1.A similar result was observed.The interaction between PLZF and hPFTAIRE1 or PCTAIRE1 was confirmed by co-immunoprecipitation assay in a yeast system.PLZF is a phosphoprotein and plays multiple roles during cell growth.Our results suggest that hPFTAIRE1 and PCTAIRE1 may play important roles in the functional regulation of PLZF." @default.
- W3151394278 created "2021-04-13" @default.
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- W3151394278 date "2006-01-01" @default.
- W3151394278 modified "2023-09-28" @default.
- W3151394278 title "Analysis of the Interaction between hPFTAIRE1 and PLZF in a Yeast Two-hybrid System" @default.
- W3151394278 hasPublicationYear "2006" @default.
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