Matches in SemOpenAlex for { <https://semopenalex.org/work/W3151450547> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W3151450547 abstract "Abstract Background: In this study, the effects of Xiao-Ban-Xia-Tang (XBXT) formula on cisplatin and 1-phenylbiguanide hydrochloride (1-PBG) induced acute and delayed emesis and gut microbiota were studied in the pica model of rats, compared with ondansetron. Methods: Two rat models of cisplatin and 1-PBG induced pica were established, the amount of kaolin intake was observed, and the effects of XBXT and ondansetron on the gut microbiota were further studied by 16S rDNA gene analysis. Results: The results showed that the total intake of kaolin of the rats injected with cisplatin and 1-PBG was significantly increased, and treatment of XBXT and ondansetron could significantly ameliorate the acute and delayed pica induced by cisplatin and 1-PBG. The 16S rDNA gene analysis has shown that the alpha diversity of the gut microbiota of the cisplatin and 1-PBG treated rats was significantly decreased compared with the control group, and ondansetron could further decrease the alpha diversity of the gut microbiota of the rats treated with cisplatin. Ondansetron significantly decreased the relative abundance of Firmicutes and increased the abundance of Bacteroidetes on phylum level in the cisplatin and 1-PBG treated rats, while XBXT only decreased Firmicutes in the cisplatin treated rats. Conclusions: XBXT was as effective as ondansetron in the treatment of acute and delayed pica induced by cisplatin and 1-PBG in rats. Ondansetron was more likely to cause gut microbiota dysbiosis than XBXT. Our study provided new avenues for the roles and mechanisms of XBXT on the prevention and treatment of CINV." @default.
- W3151450547 created "2021-04-13" @default.
- W3151450547 creator A5020946235 @default.
- W3151450547 creator A5023560083 @default.
- W3151450547 creator A5024812165 @default.
- W3151450547 creator A5050280125 @default.
- W3151450547 creator A5058781414 @default.
- W3151450547 creator A5090385327 @default.
- W3151450547 date "2020-08-11" @default.
- W3151450547 modified "2023-09-26" @default.
- W3151450547 title "Effects of Xiao-Ban-Xia-Tang Formula on Cisplatin and 1-phenylbiguanide Hydrochloride Induced Emesis and Gut Microbiota in the Pica Model of Rats" @default.
- W3151450547 doi "https://doi.org/10.21203/rs.3.rs-53216/v1" @default.
- W3151450547 hasPublicationYear "2020" @default.
- W3151450547 type Work @default.
- W3151450547 sameAs 3151450547 @default.
- W3151450547 citedByCount "0" @default.
- W3151450547 crossrefType "posted-content" @default.
- W3151450547 hasAuthorship W3151450547A5020946235 @default.
- W3151450547 hasAuthorship W3151450547A5023560083 @default.
- W3151450547 hasAuthorship W3151450547A5024812165 @default.
- W3151450547 hasAuthorship W3151450547A5050280125 @default.
- W3151450547 hasAuthorship W3151450547A5058781414 @default.
- W3151450547 hasAuthorship W3151450547A5090385327 @default.
- W3151450547 hasBestOaLocation W31514505471 @default.
- W3151450547 hasConcept C104317684 @default.
- W3151450547 hasConcept C126322002 @default.
- W3151450547 hasConcept C134018914 @default.
- W3151450547 hasConcept C203014093 @default.
- W3151450547 hasConcept C2776694085 @default.
- W3151450547 hasConcept C2777170512 @default.
- W3151450547 hasConcept C2777385719 @default.
- W3151450547 hasConcept C2777695942 @default.
- W3151450547 hasConcept C2778239845 @default.
- W3151450547 hasConcept C2780852908 @default.
- W3151450547 hasConcept C42062724 @default.
- W3151450547 hasConcept C42219234 @default.
- W3151450547 hasConcept C539455810 @default.
- W3151450547 hasConcept C55493867 @default.
- W3151450547 hasConcept C71924100 @default.
- W3151450547 hasConcept C86803240 @default.
- W3151450547 hasConcept C98274493 @default.
- W3151450547 hasConceptScore W3151450547C104317684 @default.
- W3151450547 hasConceptScore W3151450547C126322002 @default.
- W3151450547 hasConceptScore W3151450547C134018914 @default.
- W3151450547 hasConceptScore W3151450547C203014093 @default.
- W3151450547 hasConceptScore W3151450547C2776694085 @default.
- W3151450547 hasConceptScore W3151450547C2777170512 @default.
- W3151450547 hasConceptScore W3151450547C2777385719 @default.
- W3151450547 hasConceptScore W3151450547C2777695942 @default.
- W3151450547 hasConceptScore W3151450547C2778239845 @default.
- W3151450547 hasConceptScore W3151450547C2780852908 @default.
- W3151450547 hasConceptScore W3151450547C42062724 @default.
- W3151450547 hasConceptScore W3151450547C42219234 @default.
- W3151450547 hasConceptScore W3151450547C539455810 @default.
- W3151450547 hasConceptScore W3151450547C55493867 @default.
- W3151450547 hasConceptScore W3151450547C71924100 @default.
- W3151450547 hasConceptScore W3151450547C86803240 @default.
- W3151450547 hasConceptScore W3151450547C98274493 @default.
- W3151450547 hasLocation W31514505471 @default.
- W3151450547 hasOpenAccess W3151450547 @default.
- W3151450547 hasPrimaryLocation W31514505471 @default.
- W3151450547 hasRelatedWork W1987269310 @default.
- W3151450547 hasRelatedWork W2492067870 @default.
- W3151450547 hasRelatedWork W2968290483 @default.
- W3151450547 hasRelatedWork W3025414367 @default.
- W3151450547 hasRelatedWork W3093964797 @default.
- W3151450547 hasRelatedWork W4228997719 @default.
- W3151450547 hasRelatedWork W4240573699 @default.
- W3151450547 hasRelatedWork W4254773358 @default.
- W3151450547 hasRelatedWork W4320728314 @default.
- W3151450547 hasRelatedWork W4381660931 @default.
- W3151450547 isParatext "false" @default.
- W3151450547 isRetracted "false" @default.
- W3151450547 magId "3151450547" @default.
- W3151450547 workType "article" @default.