Matches in SemOpenAlex for { <https://semopenalex.org/work/W3151539310> ?p ?o ?g. }
- W3151539310 endingPage "122" @default.
- W3151539310 startingPage "105" @default.
- W3151539310 abstract "Lennox-Gastaut syndrome is considered an epileptic encephalopathy. The encephalopathy is the result of epileptic activity (epileptic encephalopathy) with or without developmental problems (developmental encephalopathy). This syndrome is defined by a triad of multiple drug-resistant seizure types, a specific EEG pattern, and intellectual disability. The prevalence of Lennox-Gastaut syndrome is estimated between 1% and 2% of all patients with epilepsy. The etiology of Lennox-Gastaut syndrome is often divided into two groups: identifiable (genetic-structural-metabolic) in 65–75% of the patients and Lennox-Gastaut syndrome of unknown cause in others. The seizures in Lennox-Gastaut syndrome are usually drug-resistant. Reduction in the frequency of the most incapacitating seizures should be the major objective. Valproate, lamotrigine and topiramate are considered to be the first-line drugs by many experts. Other effective drugs include levetiracetam, clobazam, rufinamide, and zonisamide. New antiepileptic medications such as fenfluramine HCl and sulthiame are gaining interest due to their effects on seizure reduction in patients with Lennox-Gastaut syndrome. The ketogenic diet is an effective treatment option. For patients with drug-resistance, a further therapeutic option is surgical intervention. Corpus callosotomy is a palliative surgical procedure that aims at controlling the most injurious seizures. Vagus nerve stimulation also offers reasonable seizure improvement. The long-term outcome for patients with Lennox-Gastaut syndrome is generally poor." @default.
- W3151539310 created "2021-04-13" @default.
- W3151539310 creator A5027040001 @default.
- W3151539310 creator A5052545529 @default.
- W3151539310 date "2022-01-01" @default.
- W3151539310 modified "2023-09-25" @default.
- W3151539310 title "Lennox-Gastaut Syndrome" @default.
- W3151539310 cites W1663220150 @default.
- W3151539310 cites W1671458509 @default.
- W3151539310 cites W1857838684 @default.
- W3151539310 cites W1971193889 @default.
- W3151539310 cites W1974276410 @default.
- W3151539310 cites W1976523811 @default.
- W3151539310 cites W1979023844 @default.
- W3151539310 cites W1988940197 @default.
- W3151539310 cites W1989957365 @default.
- W3151539310 cites W1991883951 @default.
- W3151539310 cites W1998000482 @default.
- W3151539310 cites W2000739510 @default.
- W3151539310 cites W2003199554 @default.
- W3151539310 cites W2004417803 @default.
- W3151539310 cites W2005548373 @default.
- W3151539310 cites W2010739389 @default.
- W3151539310 cites W2011681872 @default.
- W3151539310 cites W2015967848 @default.
- W3151539310 cites W2017055530 @default.
- W3151539310 cites W2018483913 @default.
- W3151539310 cites W2019789061 @default.
- W3151539310 cites W2024049796 @default.
- W3151539310 cites W2025153671 @default.
- W3151539310 cites W2026555458 @default.
- W3151539310 cites W2030288325 @default.
- W3151539310 cites W2031553719 @default.
- W3151539310 cites W2031722613 @default.
- W3151539310 cites W2040021578 @default.
- W3151539310 cites W2040553265 @default.
- W3151539310 cites W2043632837 @default.
- W3151539310 cites W2052972610 @default.
- W3151539310 cites W2058764682 @default.
- W3151539310 cites W2061631774 @default.
- W3151539310 cites W2071251323 @default.
- W3151539310 cites W2076133645 @default.
- W3151539310 cites W2079633037 @default.
- W3151539310 cites W2081380386 @default.
- W3151539310 cites W2089238527 @default.
- W3151539310 cites W2093392404 @default.
- W3151539310 cites W2093923585 @default.
- W3151539310 cites W2100570075 @default.
- W3151539310 cites W2130185107 @default.
- W3151539310 cites W2131407189 @default.
- W3151539310 cites W2137728866 @default.
- W3151539310 cites W2139950207 @default.
- W3151539310 cites W2140279143 @default.
- W3151539310 cites W2144996528 @default.
- W3151539310 cites W2147974822 @default.
- W3151539310 cites W2151729238 @default.
- W3151539310 cites W2211460847 @default.
- W3151539310 cites W2279576977 @default.
- W3151539310 cites W2290620956 @default.
- W3151539310 cites W2297092702 @default.
- W3151539310 cites W2333219292 @default.
- W3151539310 cites W2591683043 @default.
- W3151539310 cites W2592509339 @default.
- W3151539310 cites W2596598505 @default.
- W3151539310 cites W2606268204 @default.
- W3151539310 cites W2614859754 @default.
- W3151539310 cites W2767480397 @default.
- W3151539310 cites W2768625710 @default.
- W3151539310 cites W2889968052 @default.
- W3151539310 cites W2894484912 @default.
- W3151539310 cites W2990728213 @default.
- W3151539310 cites W4239594659 @default.
- W3151539310 cites W4252563651 @default.
- W3151539310 cites W4254024896 @default.
- W3151539310 doi "https://doi.org/10.1016/b978-0-12-820472-6.00043-8" @default.
- W3151539310 hasPublicationYear "2022" @default.
- W3151539310 type Work @default.
- W3151539310 sameAs 3151539310 @default.
- W3151539310 citedByCount "0" @default.
- W3151539310 crossrefType "book-chapter" @default.
- W3151539310 hasAuthorship W3151539310A5027040001 @default.
- W3151539310 hasAuthorship W3151539310A5052545529 @default.
- W3151539310 hasConcept C118552586 @default.
- W3151539310 hasConcept C187212893 @default.
- W3151539310 hasConcept C2777138316 @default.
- W3151539310 hasConcept C2777332695 @default.
- W3151539310 hasConcept C2777683783 @default.
- W3151539310 hasConcept C2777907850 @default.
- W3151539310 hasConcept C2778186239 @default.
- W3151539310 hasConcept C2778587478 @default.
- W3151539310 hasConcept C2778734009 @default.
- W3151539310 hasConcept C2778802184 @default.
- W3151539310 hasConcept C2778815751 @default.
- W3151539310 hasConcept C2779307984 @default.
- W3151539310 hasConcept C2780803581 @default.
- W3151539310 hasConcept C2780874087 @default.
- W3151539310 hasConcept C2910479173 @default.
- W3151539310 hasConcept C2910833928 @default.