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• W3151582534 abstract "Objective: To study the status of fibrinolytic inhibition in patients with acute coronary syndrome(ACS) complicated with impaired glucose tolerance (IGT) and to evaluate the effect of fibrinolytic inhibition on treatment and prognosis. Methods: The subjects were divided into three groups included 39 patients with ACS without diabetes mellitus, 37 patients with IGT+ACS and 36 patients with ACS+ noninsulindependent diabetes mellitus (NIDDM). Twenty healthy people were randomized to be control group. The plasma levels of tissue type plasminogen activator(tPA), plasminogen activator inhibitor type1 (PAI1) and plasma Ddimer were detected by enzyme linked immunoadsorbent assay(ELISA) technique. The index of status of fibrinolysis was detected with the plasma levels of PAI1, Ddimer and the ratio of PAI1/Ddimer. This index was used to evaluate the status of fibrinolytic inhibition and the clinical out come in patients with AMI. Results: Plasma level of PAI1 was significantly higher in IGT+ACS patients and NIDDM +ACS patients than that in ACS( P 0 05), but the plasma level of Ddimer raised from basic level was significantly lower in IGT+ACS patients and NIDDM +ACS patients than that in ACS( P 0 05). The ratio of PAI1/Ddimer was significantly higher in IGT+ACS patients and NIDDM +ACS patients than that in ACS or in control group( P 0 01). For AMI patients in treatment groups, the rate of reperfusion after the thrombolytic was significantly lower and the rate of incidences in pump failure was significantly higher in IGT+ACS patients and NIDDM +ACS patients than that in ACS, too( P 0 01 and P 0 05) . The incidences of serious arrhythmia, reinfarction and death were also higher in IGT+ACS patients and NIDDM +ACS patients. Conclusion: The fibrinolytic inhibition is existed in IGT+ACS group patients . The plasma level of Ddimer combined with the ratio of PAI1/Ddimer could be used to be the evidence and to be the index to evaluate the status of fibrinolytic inhibition and prognosis." @default.
• W3151582534 created "2021-04-13" @default.
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• W3151582534 date "2003-01-01" @default.
• W3151582534 modified "2023-09-25" @default.
• W3151582534 title "Evolution of fibrinolysis status with D-dimer level and the rate of plasminogen activator inhibitor type-1/ D-dimer in acute coronary syndrome patients complicated with impaired glucose tolerance" @default.
• W3151582534 hasPublicationYear "2003" @default.
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