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- W3151590869 abstract "从锥蜗牛(Conus ) 的毒液的充满半胱氨酸的肽指向许多不同离子隧道。conopeptides 的一个家庭，伪 - conotoxins，明确地指向在神经与肌的连接和中央神经系统两个都发现的烟碱的醋胆素受体(nAChRs ) 的不同 isoforms。这个家庭进一步基于在半胱氨酸残余之间的氨基酸的数字被划分成亚科。某些伪 - conotoxins 的优美子类型选择对涉及 neurotransmitter 版本的调整的本国的 nAChR isoforms 的描述关键， Parkinson 的疾病和 nociception 的 pathophysiology。伪 - conotoxins 的结构 / 功能描述与改进力量或子类型选择导致了类似物的发展。脊梁结构的环合和脂性的一半的增加导致了伪 - conotoxins 的改进稳定性和 bioavailability，因此为口头上地可得到的治疗学铺平道路。在发展史， exogenomics 和分子的建模诺言的最近的进展有为 nAChRs 的特定的子类型的改进选择的伪 - conotoxins 和类似物的一个甚至更大的数字的发现。" @default.
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- W3151590869 date "2009-01-01" @default.
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- W3151590869 title "Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors" @default.
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