Matches in SemOpenAlex for { <https://semopenalex.org/work/W3151679571> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3151679571 endingPage "400" @default.
- W3151679571 startingPage "396" @default.
- W3151679571 abstract "背景干扰素(IFN ) 能禁止人的免疫不全病毒类型 1 (HIV-1 ) 在 vitro 并且在 clinic.However 的复制，为 HIV 感染的 IFN 治疗被它的中等抗病毒的功效和它的经常的不利效果限制。在现在的学习，我们评估了我们在 vitro 执行了的干扰素( slFN ) .Methods 与 HIV-1 IIB 试验的新奇综合上级的 anti-HIV 功效感染的 MT4 房间，并且在严重联合 immunodeficient ( SClD )在 slFN 的 vivo anti-HIV 功效评估了老鼠与人的外部血白血球( hu-PBL-SClD 老鼠)重新组成我们发现了的 .Results 对在 MT4 房间的 HIV-1 的复制的 slFN 的50%有效集中( EC5o )是 0.06 ng/ml ，代表更强壮的 antiv 在 hu-PBL-SCID 老鼠，一个剂量依赖者保护模式被观察：与 0.45 g 和 1.35 个 g slFN 日报处理，而 2.25 个 g sIFN 日报处理导致了严重地完全的 protection.Conclusions slFN ， SCID 老鼠的部分被保护免受 HIV 感染的伤害显示出好 anti-HIV 在 vitro 并且在 SCID 老鼠的活动，可以是值得临床的调查的一个有希望的 anti-HIV 代理人，特别认为IFN-的潜力在病人禁止 HIV 复制与药抵抗的变体感染了或与丙肝病毒( HCV )共同感染。" @default.
- W3151679571 created "2021-04-13" @default.
- W3151679571 creator A5001978013 @default.
- W3151679571 creator A5008108990 @default.
- W3151679571 creator A5015398167 @default.
- W3151679571 creator A5024034517 @default.
- W3151679571 creator A5025879011 @default.
- W3151679571 creator A5025988507 @default.
- W3151679571 creator A5036471126 @default.
- W3151679571 creator A5049375802 @default.
- W3151679571 creator A5052829662 @default.
- W3151679571 creator A5056462771 @default.
- W3151679571 creator A5058918418 @default.
- W3151679571 creator A5060073997 @default.
- W3151679571 creator A5077360509 @default.
- W3151679571 creator A5086075979 @default.
- W3151679571 date "2011-01-01" @default.
- W3151679571 modified "2023-09-26" @default.
- W3151679571 title "Activity of superior interferon α against HIV-1 in severe combined immunodeficient mice reconstituted with human peripheral blood leukocytes" @default.
- W3151679571 hasPublicationYear "2011" @default.
- W3151679571 type Work @default.
- W3151679571 sameAs 3151679571 @default.
- W3151679571 citedByCount "0" @default.
- W3151679571 crossrefType "journal-article" @default.
- W3151679571 hasAuthorship W3151679571A5001978013 @default.
- W3151679571 hasAuthorship W3151679571A5008108990 @default.
- W3151679571 hasAuthorship W3151679571A5015398167 @default.
- W3151679571 hasAuthorship W3151679571A5024034517 @default.
- W3151679571 hasAuthorship W3151679571A5025879011 @default.
- W3151679571 hasAuthorship W3151679571A5025988507 @default.
- W3151679571 hasAuthorship W3151679571A5036471126 @default.
- W3151679571 hasAuthorship W3151679571A5049375802 @default.
- W3151679571 hasAuthorship W3151679571A5052829662 @default.
- W3151679571 hasAuthorship W3151679571A5056462771 @default.
- W3151679571 hasAuthorship W3151679571A5058918418 @default.
- W3151679571 hasAuthorship W3151679571A5060073997 @default.
- W3151679571 hasAuthorship W3151679571A5077360509 @default.
- W3151679571 hasAuthorship W3151679571A5086075979 @default.
- W3151679571 hasConcept C159047783 @default.
- W3151679571 hasConcept C202751555 @default.
- W3151679571 hasConcept C203014093 @default.
- W3151679571 hasConcept C207001950 @default.
- W3151679571 hasConcept C2776178377 @default.
- W3151679571 hasConcept C3013748606 @default.
- W3151679571 hasConcept C3017910909 @default.
- W3151679571 hasConcept C54355233 @default.
- W3151679571 hasConcept C71924100 @default.
- W3151679571 hasConcept C86803240 @default.
- W3151679571 hasConceptScore W3151679571C159047783 @default.
- W3151679571 hasConceptScore W3151679571C202751555 @default.
- W3151679571 hasConceptScore W3151679571C203014093 @default.
- W3151679571 hasConceptScore W3151679571C207001950 @default.
- W3151679571 hasConceptScore W3151679571C2776178377 @default.
- W3151679571 hasConceptScore W3151679571C3013748606 @default.
- W3151679571 hasConceptScore W3151679571C3017910909 @default.
- W3151679571 hasConceptScore W3151679571C54355233 @default.
- W3151679571 hasConceptScore W3151679571C71924100 @default.
- W3151679571 hasConceptScore W3151679571C86803240 @default.
- W3151679571 hasIssue "3" @default.
- W3151679571 hasLocation W31516795711 @default.
- W3151679571 hasOpenAccess W3151679571 @default.
- W3151679571 hasPrimaryLocation W31516795711 @default.
- W3151679571 hasRelatedWork W1548119113 @default.
- W3151679571 hasRelatedWork W1664913738 @default.
- W3151679571 hasRelatedWork W1879839008 @default.
- W3151679571 hasRelatedWork W1973434464 @default.
- W3151679571 hasRelatedWork W2016823797 @default.
- W3151679571 hasRelatedWork W2018541629 @default.
- W3151679571 hasRelatedWork W2025458528 @default.
- W3151679571 hasRelatedWork W2033741395 @default.
- W3151679571 hasRelatedWork W2035286469 @default.
- W3151679571 hasRelatedWork W2048579738 @default.
- W3151679571 hasRelatedWork W2080800959 @default.
- W3151679571 hasRelatedWork W2110204163 @default.
- W3151679571 hasRelatedWork W2116218257 @default.
- W3151679571 hasRelatedWork W2124827313 @default.
- W3151679571 hasRelatedWork W2126888921 @default.
- W3151679571 hasRelatedWork W2408183011 @default.
- W3151679571 hasRelatedWork W2528082263 @default.
- W3151679571 hasRelatedWork W3149711961 @default.
- W3151679571 hasRelatedWork W315170245 @default.
- W3151679571 hasRelatedWork W290066654 @default.
- W3151679571 isParatext "false" @default.
- W3151679571 isRetracted "false" @default.
- W3151679571 magId "3151679571" @default.
- W3151679571 workType "article" @default.