Matches in SemOpenAlex for { <https://semopenalex.org/work/W315170245> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W315170245 endingPage "400" @default.
- W315170245 startingPage "396" @default.
- W315170245 abstract "Interferon (IFN) can inhibit human immunodeficiency virus type 1 (HIV-1) replication in vitro and in clinic. However, IFN therapy for HIV infection was limited by its moderate antiviral efficacy and its frequent adverse effects. In the present study we evaluated the anti-HIV efficacy of a novel synthesized superior interferon α (sIFNα).We performed in vitro experiments with HIV-1 IIIB infected MT4 cells, and evaluated in vivo anti-HIV efficacy of sIFNα in severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID mice).We found that the 50% effective concentrations (EC(50)) of sIFNα against the replication of HIV-1 in MT4 cells was 0.06 ng/ml, representing stronger antiviral activity than interferon-α in vitro. In the hu-PBL-SCID mice, a dose-dependent protection pattern was observed: with 0.45 µg and 1.35 µg sIFNα daily treatments, parts of SCID mice were protected from HIV infection, whereas 2.25 µg sIFNα daily treatments resulted in a terminally complete protection.sIFNα shows good anti-HIV activity both in vitro and in SCID mice, may be a promising anti-HIV agent deserving clinical investigation, especially considering the potential of IFN-α to inhibit HIV replication in patients infected with drug-resistant variants or co-infected with hepatitis C virus (HCV)." @default.
- W315170245 created "2016-06-24" @default.
- W315170245 creator A5006845416 @default.
- W315170245 creator A5014863278 @default.
- W315170245 creator A5034676224 @default.
- W315170245 creator A5038730071 @default.
- W315170245 creator A5039005272 @default.
- W315170245 creator A5042119566 @default.
- W315170245 creator A5049803928 @default.
- W315170245 date "2011-02-01" @default.
- W315170245 modified "2023-09-27" @default.
- W315170245 title "Activity of superior interferon α against HIV-1 in severe combined immunodeficient mice reconstituted with human peripheral blood leukocytes." @default.
- W315170245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21362340" @default.
- W315170245 hasPublicationYear "2011" @default.
- W315170245 type Work @default.
- W315170245 sameAs 315170245 @default.
- W315170245 citedByCount "1" @default.
- W315170245 countsByYear W3151702452017 @default.
- W315170245 crossrefType "journal-article" @default.
- W315170245 hasAuthorship W315170245A5006845416 @default.
- W315170245 hasAuthorship W315170245A5014863278 @default.
- W315170245 hasAuthorship W315170245A5034676224 @default.
- W315170245 hasAuthorship W315170245A5038730071 @default.
- W315170245 hasAuthorship W315170245A5039005272 @default.
- W315170245 hasAuthorship W315170245A5042119566 @default.
- W315170245 hasAuthorship W315170245A5049803928 @default.
- W315170245 hasConcept C140704245 @default.
- W315170245 hasConcept C150903083 @default.
- W315170245 hasConcept C159047783 @default.
- W315170245 hasConcept C159110408 @default.
- W315170245 hasConcept C202751555 @default.
- W315170245 hasConcept C203014093 @default.
- W315170245 hasConcept C207001950 @default.
- W315170245 hasConcept C2522874641 @default.
- W315170245 hasConcept C2775944032 @default.
- W315170245 hasConcept C2776178377 @default.
- W315170245 hasConcept C2776408679 @default.
- W315170245 hasConcept C2776999253 @default.
- W315170245 hasConcept C2909179924 @default.
- W315170245 hasConcept C3013748606 @default.
- W315170245 hasConcept C49453240 @default.
- W315170245 hasConcept C55493867 @default.
- W315170245 hasConcept C64943373 @default.
- W315170245 hasConcept C71924100 @default.
- W315170245 hasConcept C86803240 @default.
- W315170245 hasConcept C98274493 @default.
- W315170245 hasConceptScore W315170245C140704245 @default.
- W315170245 hasConceptScore W315170245C150903083 @default.
- W315170245 hasConceptScore W315170245C159047783 @default.
- W315170245 hasConceptScore W315170245C159110408 @default.
- W315170245 hasConceptScore W315170245C202751555 @default.
- W315170245 hasConceptScore W315170245C203014093 @default.
- W315170245 hasConceptScore W315170245C207001950 @default.
- W315170245 hasConceptScore W315170245C2522874641 @default.
- W315170245 hasConceptScore W315170245C2775944032 @default.
- W315170245 hasConceptScore W315170245C2776178377 @default.
- W315170245 hasConceptScore W315170245C2776408679 @default.
- W315170245 hasConceptScore W315170245C2776999253 @default.
- W315170245 hasConceptScore W315170245C2909179924 @default.
- W315170245 hasConceptScore W315170245C3013748606 @default.
- W315170245 hasConceptScore W315170245C49453240 @default.
- W315170245 hasConceptScore W315170245C55493867 @default.
- W315170245 hasConceptScore W315170245C64943373 @default.
- W315170245 hasConceptScore W315170245C71924100 @default.
- W315170245 hasConceptScore W315170245C86803240 @default.
- W315170245 hasConceptScore W315170245C98274493 @default.
- W315170245 hasIssue "3" @default.
- W315170245 hasLocation W3151702451 @default.
- W315170245 hasOpenAccess W315170245 @default.
- W315170245 hasPrimaryLocation W3151702451 @default.
- W315170245 hasRelatedWork W1548119113 @default.
- W315170245 hasRelatedWork W1628519062 @default.
- W315170245 hasRelatedWork W1664913738 @default.
- W315170245 hasRelatedWork W1879839008 @default.
- W315170245 hasRelatedWork W1970874555 @default.
- W315170245 hasRelatedWork W1973434464 @default.
- W315170245 hasRelatedWork W2008403406 @default.
- W315170245 hasRelatedWork W2016823797 @default.
- W315170245 hasRelatedWork W2018541629 @default.
- W315170245 hasRelatedWork W2025458528 @default.
- W315170245 hasRelatedWork W2033741395 @default.
- W315170245 hasRelatedWork W2035286469 @default.
- W315170245 hasRelatedWork W2036527166 @default.
- W315170245 hasRelatedWork W2048579738 @default.
- W315170245 hasRelatedWork W2080800959 @default.
- W315170245 hasRelatedWork W2110204163 @default.
- W315170245 hasRelatedWork W2124827313 @default.
- W315170245 hasRelatedWork W2408183011 @default.
- W315170245 hasRelatedWork W3151679571 @default.
- W315170245 hasRelatedWork W290066654 @default.
- W315170245 hasVolume "124" @default.
- W315170245 isParatext "false" @default.
- W315170245 isRetracted "false" @default.
- W315170245 magId "315170245" @default.
- W315170245 workType "article" @default.