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- W3151829158 endingPage "114074" @default.
- W3151829158 startingPage "114074" @default.
- W3151829158 abstract "Carica papaya leaf juice/decoction has been in use in folk medicine in Srilanka, Malaysia and in few parts of India for enhancing the platelet counts in dengue. In Siddha medicine, a traditional form of medicine in India, papaya leaf juice has been used for increasing the platelet counts. Papaya leaf has been reported to enhance blood volume in ancient Ayurveda books in India. Carica papaya leaf is well known for its platelet enhancement activity. Although many preclinical and clinical studies have demonstrated the ability of papaya leaf juice for platelet enhancement, but the underlying mechanisms are still unclear. The study is aimed at identifying the key ingredients of papaya leaf extract and elucidate the mechanism (s) of action of the identified potent component in mitigating thrombocytopenia (Thp). C. papaya leaf juice was subjected for sequential fractionation to identify the anti-thrombocytopenic phytochemicals. In vivo , stable thrombocytopenia was induced by subcutaneous injection of 70 mg/kg cyclophosphamide (Cyp). After induction, rats were treated with 200 and 400 mg/kg body weight papaya leaf juice and with identified fractions for 14 days. Serum thrombopoietin level was estimated using ELISA. CD110/cMpl, a receptor for thrombopoietin on platelets was measured by western blotting. Administration of cyclophosphamide for 6 days induced thrombocytopenia (210.4 ± 14.2 × 10 3 cells/μL) in rats. Treating thrombocytopenic rats with papaya leaf juice and butanol fraction for 14 days significantly increased the platelet count to 1073.50 ± 29.6 and 1189.80 ± 36.5 × 10 3 cells/μL, respectively. C.papaya extracts normalized the elevated bleeding and clotting time and decreased oxidative markers by increasing endogenous antioxidants. A marginal increase in the serum thrombopoietin (TPO) level was observed in Cyp treated group compared to normal and treatment groups. Low expression of CD110/cMpl receptor found in Cyp treated group was enhanced by C. papaya extracts (CPJ) and CPJ-BT. Furthermore, examination of the morphology of bone marrow megakaryocytes, histopathology of liver and kidneys revealed the ability of CPJ and fractions in mitigating Cyp-induced thrombocytopenia in rats. C. papaya leaf juice enhances the platelet count in chemotherapy-induced thrombocytopenia by increasing the expression of CD110 receptor on the megakaryocytes. Hence, activating CD110 receptor might be a viable strategy to increase the platelet production in individuals suffering from thrombocytopenia." @default.
- W3151829158 created "2021-04-13" @default.
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- W3151829158 date "2021-07-01" @default.
- W3151829158 modified "2023-09-27" @default.
- W3151829158 title "Platelet enhancement by Carica papaya L. leaf fractions in cyclophosphamide induced thrombocytopenic rats is due to elevated expression of CD110 receptor on megakaryocytes" @default.
- W3151829158 cites W131887615 @default.
- W3151829158 cites W1526662853 @default.
- W3151829158 cites W1582189787 @default.
- W3151829158 cites W1596391559 @default.
- W3151829158 cites W1750690213 @default.
- W3151829158 cites W1895009500 @default.
- W3151829158 cites W191793640 @default.
- W3151829158 cites W1981317886 @default.
- W3151829158 cites W1983310681 @default.
- W3151829158 cites W1983934675 @default.
- W3151829158 cites W1984069221 @default.
- W3151829158 cites W1985368700 @default.
- W3151829158 cites W1996837920 @default.
- W3151829158 cites W2006370393 @default.
- W3151829158 cites W2009094928 @default.
- W3151829158 cites W2009253660 @default.
- W3151829158 cites W2013069297 @default.
- W3151829158 cites W2020779110 @default.
- W3151829158 cites W2021671093 @default.
- W3151829158 cites W2034544924 @default.
- W3151829158 cites W2035185745 @default.
- W3151829158 cites W2038178012 @default.
- W3151829158 cites W2040737693 @default.
- W3151829158 cites W2043542213 @default.
- W3151829158 cites W2045225337 @default.
- W3151829158 cites W2052205473 @default.
- W3151829158 cites W2053722789 @default.
- W3151829158 cites W2054162904 @default.
- W3151829158 cites W2065221742 @default.
- W3151829158 cites W2065781948 @default.
- W3151829158 cites W2069547558 @default.
- W3151829158 cites W2079732181 @default.
- W3151829158 cites W2085017979 @default.
- W3151829158 cites W2085542936 @default.
- W3151829158 cites W2090080882 @default.
- W3151829158 cites W2103398208 @default.
- W3151829158 cites W2103900283 @default.
- W3151829158 cites W2109578658 @default.
- W3151829158 cites W2117996963 @default.
- W3151829158 cites W2120384996 @default.
- W3151829158 cites W2123312213 @default.
- W3151829158 cites W2130039646 @default.
- W3151829158 cites W2132458868 @default.
- W3151829158 cites W2146447506 @default.
- W3151829158 cites W2146974608 @default.
- W3151829158 cites W2147541161 @default.
- W3151829158 cites W2150650800 @default.
- W3151829158 cites W2154267460 @default.
- W3151829158 cites W2161307297 @default.
- W3151829158 cites W2165282007 @default.
- W3151829158 cites W2166657263 @default.
- W3151829158 cites W2170371593 @default.
- W3151829158 cites W2174762922 @default.
- W3151829158 cites W2201119014 @default.
- W3151829158 cites W2259469242 @default.
- W3151829158 cites W2260760629 @default.
- W3151829158 cites W2289516778 @default.
- W3151829158 cites W2307253401 @default.
- W3151829158 cites W2323050569 @default.
- W3151829158 cites W2362452865 @default.
- W3151829158 cites W2403101744 @default.
- W3151829158 cites W2463749973 @default.
- W3151829158 cites W2521392361 @default.
- W3151829158 cites W2571511053 @default.
- W3151829158 cites W2608179938 @default.
- W3151829158 cites W2625029096 @default.
- W3151829158 cites W272601212 @default.
- W3151829158 cites W2731472079 @default.
- W3151829158 cites W2749240194 @default.
- W3151829158 cites W2753542830 @default.
- W3151829158 cites W2767280722 @default.
- W3151829158 cites W2770742962 @default.
- W3151829158 cites W2789895359 @default.
- W3151829158 cites W2793364737 @default.
- W3151829158 cites W2810460447 @default.
- W3151829158 cites W2811101425 @default.
- W3151829158 cites W2902040935 @default.
- W3151829158 cites W2937867957 @default.
- W3151829158 cites W3006750249 @default.
- W3151829158 cites W3107225299 @default.
- W3151829158 cites W4297845837 @default.
- W3151829158 doi "https://doi.org/10.1016/j.jep.2021.114074" @default.
- W3151829158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33831466" @default.
- W3151829158 hasPublicationYear "2021" @default.
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