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- W3151830174 abstract "瞄准：在极化的 CFPAC-1 描绘 H+ 和 HCO3- 运输 ers 人的胰腺的管房间，它与 DeltaF508 CFTR 变化从一个膀胱的纤维变性病人被导出。方法：CFPAC-1 房间在高密度被播种到可渗透的支持上并且成长到融合。房间与 pH 敏感的荧光灯的染料 BCECF 被装载，并且增长了进一个灌注房间，它允许 basolateral 和顶端的膜的同时的灌注。Transmembrane 基础流动在细胞内部的 pH 和房间的缓冲能力从变化被计算。结果：我们的结果显示出微分渗透到 HCO3-/CO2 在顶端并且 CFPAC-1 房间的 basolateral 膜。Na+/HCO3- co-transporters (NBC ) 和 Cl-/HCO3- exchangers (AE ) 在两个上在 basolateral 膜，和 Na+/H+ exchangers (NHE ) 上是在场的顶端并且房间的 basolateral 膜。Basolateral HCO3- 举起对细胞外的 K+ 集中的变化敏感，膜可渗透的碳酸酐酶(CA ) 禁止者乙酰唑胺(100 micromol/L ) 和 ethoxyzolamide (100 micromol/L ) ，并且被 H2do (600 micromol/L ) 部分禁止。膜透不过的 CA 禁止者 1-N-(4-sulfamoylphenylethyl )-2,4,6-trimethylpyridine 高氯酸盐没在 HCO3- 举起上有任何效果。basolateral AE 在顶端的膜比那举办了一项高得多的活动，而没有有在放松条件下面的 NHE 的如此的差别。另外， 10 micromol/L forskolin 显著地没影响 Cl-/HCO3- 交换在上顶端并且 basolateral 膜。250 micromol/L H2do 的管理显著地禁止了 basolateral AE。Amiloride (300 micromol/L ) 完全在房间的两膜上禁止了 NHE。RT-PCR 揭示了 pNBC1， AE2，和 NHE1 mRNA 的表示。结论：这些数据建议除了 CFTR 和顶端的 Cl-/HCO3- exchanger 活动的缺乏， CFPAC-1 细胞表示类似的 H+ 和 HCO3- 运输 ers 到在本国的动物织物观察的那些。" @default.
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- W3151830174 date "2006-01-01" @default.
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- W3151830174 title "Characterization of H^＋ and HCO3^- transporters in CFPAC-1 human pancreatic duct cells" @default.
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