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- W3151869337 endingPage "107846" @default.
- W3151869337 startingPage "107846" @default.
- W3151869337 abstract "Chronic pain remains an enormous health problem affecting approximatively 30% of the world's population. Opioids as the first line analgesics often leads to undesirable side effects when used long term. Therefore, novel therapeutic targets are urgently needed to the development of more efficacious analgesics. Substantial evidence indicates that excessive reactive oxygen species (ROS) are extremely important to the development of chronic pain. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master transcription factor regulating endogenous antioxidant defense. Emerging evidence suggests that Nrf2 and its downstream effectors are implicated in chronic inflammatory and neuropathic pain. Notably, controversial results have been reported regarding the expression of Nrf2 and its downstream targets in peripheral and central regions involved in pain transmission. However, our recent studies and results from other laboratories demonstrate that Nrf2 inducers exert potent analgesic effects in various murine models of chronic pain. In this review, we summarized and discussed the preclinical evidence demonstrating the therapeutic potential of Nrf2 inducers in chronic pain. These evidence indicates that Nrf2 activation are beneficial in chronic pain mostly by alleviating ROS-associated pathological processes. Overall, Nrf2-based therapy for chronic pain is an area with great promise, but more research regarding its detailed mechanisms is warranted." @default.
- W3151869337 created "2021-04-13" @default.
- W3151869337 creator A5017410860 @default.
- W3151869337 creator A5020256436 @default.
- W3151869337 creator A5023085804 @default.
- W3151869337 creator A5032223758 @default.
- W3151869337 creator A5032426675 @default.
- W3151869337 creator A5050144367 @default.
- W3151869337 date "2021-09-01" @default.
- W3151869337 modified "2023-10-16" @default.
- W3151869337 title "The therapeutic potential of Nrf2 inducers in chronic pain: Evidence from preclinical studies" @default.
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